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dipeptidyl peptidase like 6

Summary

Gene Symbol

DPP6

Organism

Homo sapiens (human)

External Links

NCBI Gene

1804

KEGG Gene ID

PubChem

1804

Alliance of Genome Resources

HGNC:3010

Annotation

Keyword

3D-structure
Alternative splicing
Aminopeptidase
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Intellectual disability
Neurodegeneration
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 8** entries
UniProt	Protein Name
E9PF59	Dipeptidyl aminopeptidase-like protein 6 Dipeptidyl peptidase 6 Dipeptidyl peptidase VI
P42658	DPPX Dipeptidyl aminopeptidase-like protein 6 Dipeptidyl aminopeptidase-related protein Dipeptidyl peptidase 6 Dipeptidyl peptidase IV-like protein Dipeptidyl peptidase VI
B7Z299	Dipeptidyl aminopeptidase-like protein 6 Dipeptidyl peptidase 6 Dipeptidyl peptidase VI
E9PDL2	Dipeptidyl aminopeptidase-like protein 6 Dipeptidyl peptidase 6 Dipeptidyl peptidase VI
A0A994J521
A7E2E4	Dipeptidyl aminopeptidase-like protein 6 Dipeptidyl peptidase 6 Dipeptidyl peptidase VI
Q8IYG9
A0A994J7K0	Dipeptidyl aminopeptidase-like protein 6 Dipeptidyl peptidase 6 Dipeptidyl peptidase VI

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
protein localization to plasma membrane	ISS
regulation of potassium ion transmembrane transport	ISS
regulation of potassium ion transmembrane transport	IDA
regulation of potassium ion transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	EXP
plasma membrane	IBA
plasma membrane	IEA
voltage-gated potassium channel complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical structure [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
aminopeptidase activity
protein binding	IPI
serine-type peptidase activity	IEA
dipeptidyl-peptidase activity	IDA
potassium channel regulator activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity

exopeptidase activity [inference]

serine hydrolase activity [inference]

serine-type peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity

exopeptidase activity [inference]

binding [inference]

protein binding

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

potassium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:12377	spinal muscular atrophy	Alliance of Genome Resources
DOID:0070063	autosomal dominant intellectual developmental disorder 33	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13483	MGI:94921
Rattus norvegicus	29272	RGD:68402
Caenorhabditis elegans	180042	WB:WBGene00001054
Saccharomyces cerevisiae S288C	854394	SGD:S000005745