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nitric oxide synthase 3, endothelial cell

Summary

Gene Symbol

Nos3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18127

KEGG Gene ID

PubChem

18127

Alliance of Genome Resources

MGI:97362

Annotation

Keyword

Calcium
Calmodulin-binding
Cell membrane
Cytoskeleton
FAD
FMN
Golgi apparatus
Heme
Myristate
NADP
Oxidoreductase
Palmitate
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8C5P3
P70313	Constitutive NOS EC-NOS NOS type III Nitric oxide synthase, endothelial

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 60 in total

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GO Term	Evidence Code	PMID
angiogenesis	IMP
ovulation from ovarian follicle	IMP
in utero embryonic development	IMP
blood vessel remodeling	IMP
regulation of the force of heart contraction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

lipopolysaccharide-mediated signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

nitric oxide mediated signal transduction

metabolic process [inference]

catabolic process [inference]

amino acid catabolic process [inference]

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

biosynthetic process [inference]

nitric oxide biosynthetic process

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid metabolic process [inference]

arginine metabolic process [inference]

L-arginine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid metabolic process [inference]

arginine metabolic process [inference]

L-arginine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-arginine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-arginine catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process [inference]

nitric oxide biosynthetic process

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

cell motility [inference]

cell migration [inference]

endothelial cell migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

reproductive process [inference]

ovulation cycle process [inference]

ovulation from ovarian follicle

multicellular organismal reproductive process [inference]

ovulation [inference]

ovulation from ovarian follicle

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle adaptation [inference]

smooth muscle adaptation [inference]

smooth muscle hyperplasia

muscle hyperplasia [inference]

smooth muscle hyperplasia

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by endothelin

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue remodeling [inference]

blood vessel remodeling

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

tissue morphogenesis [inference]

mesenchyme morphogenesis [inference]

endocardial cushion morphogenesis

cardiac septum morphogenesis [inference]

ventricular septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

lung development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

rhythmic process [inference]

ovulation cycle process [inference]

ovulation from ovarian follicle

response to stimulus [inference]

response to stress [inference]

response to fluid shear stress

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to chemical [inference]

response to hormone

response to lipid [inference]

response to oxygen-containing compound [inference]

muscle adaptation [inference]

smooth muscle adaptation [inference]

smooth muscle hyperplasia

muscle hyperplasia [inference]

smooth muscle hyperplasia

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

negative regulation of response to stimulus [inference]

negative regulation of muscle adaptation [inference]

negative regulation of muscle hyperplasia

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of developmental process [inference]

negative regulation of biomineral tissue development

negative regulation of multicellular organismal process [inference]

negative regulation of muscle adaptation [inference]

negative regulation of muscle hyperplasia

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of muscle hyperplasia [inference]

negative regulation of muscle hyperplasia

negative regulation of muscle adaptation [inference]

negative regulation of muscle hyperplasia

negative regulation of response to stimulus [inference]

negative regulation of muscle adaptation [inference]

negative regulation of muscle hyperplasia

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of biomineral tissue development

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

negative regulation of biomineral tissue development

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

lipopolysaccharide-mediated signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

nitric oxide mediated signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process

regulation of muscle system process [inference]

regulation of muscle adaptation [inference]

regulation of muscle hyperplasia [inference]

negative regulation of muscle hyperplasia

negative regulation of muscle adaptation [inference]

negative regulation of muscle hyperplasia

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

regulation of the force of heart contraction by chemical signal

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of muscle adaptation [inference]

negative regulation of muscle hyperplasia

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

negative regulation of biomineral tissue development

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of the force of heart contraction

regulation of the force of heart contraction by chemical signal

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by endothelin

negative regulation of blood pressure

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IDA
nucleus	IBA
cytoplasm	ISO
cytoplasm	IC

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

sarcolemma

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

apical part of cell

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GO Term	Evidence Code	PMID
actin binding	ISO
actin monomer binding	ISO
actin monomer binding	IEA
nitric-oxide synthase activity	ISS
nitric-oxide synthase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

nitric-oxide synthase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

nitric-oxide synthase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin monomer binding

enzyme binding [inference]

nitric-oxide synthase binding

heat shock protein binding [inference]

Hsp90 protein binding

cell adhesion molecule binding [inference]

cadherin binding

scaffold protein binding

amino acid binding [inference]

arginine binding

tetrahydrobiopterin binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

FMN binding

carboxylic acid binding [inference]

arginine binding

flavin adenine dinucleotide binding

cation binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

arginine binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ribonucleotide binding [inference]

FMN binding

flavin adenine dinucleotide binding

tetrapyrrole binding [inference]

heme binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

FMN binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ribonucleotide binding [inference]

FMN binding

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nitric oxide synthase

Functional Category

P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 5** entries
Gene Ontology
calmodulin binding
metal ion binding
nitric oxide biosynthetic process
nitric-oxide synthase activity
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Flavoprotein pyridine nucleotide cytochrome reductase
NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Oxidoreductase FAD/NAD(P)-binding
Riboflavin synthase-like beta-barrel
Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:13042	persistent fetal circulation syndrome	Alliance of Genome Resources
DOID:62	aortic valve disease	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements