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Guidelines

MIRAGE

dopamine receptor D1

Summary

Gene Symbol

DRD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1812

KEGG Gene ID

PubChem

1812

Alliance of Genome Resources

HGNC:3020

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Disulfide bond
Endoplasmic reticulum
G-protein coupled receptor
Glycoprotein
Palmitate
Proteomics identification
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P21728	Dopamine D1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 54 in total

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GO Term	Evidence Code	PMID
temperature homeostasis
conditioned taste aversion
behavioral fear response
synaptic transmission, dopaminergic	IEA
response to amphetamine

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating dopamine receptor signaling pathway

G protein-coupled dopamine receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

astrocyte development

cell motility [inference]

cell migration [inference]

neuron migration [inference]

interneuron migration [inference]

cerebral cortex GABAergic interneuron migration

forebrain cell migration [inference]

telencephalon cell migration [inference]

substrate-independent telencephalic tangential migration [inference]

substrate-independent telencephalic tangential interneuron migration [inference]

interneuron migration from the subpallium to the cortex [inference]

cerebral cortex GABAergic interneuron migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

modification of synaptic structure [inference]

modification of postsynaptic structure

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior

parental behavior [inference]

maternal behavior

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

peristalsis

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

nervous system process [inference]

transmission of nerve impulse

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

operant conditioning

nonassociative learning [inference]

memory

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

associative learning [inference]

operant conditioning

nonassociative learning [inference]

memory

grooming behavior

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

feeding behavior [inference]

conditioned taste aversion

visual behavior [inference]

visual learning

reproductive behavior [inference]

mating behavior

parental behavior [inference]

maternal behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

behavioral response to cocaine

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

multicellular organismal-level homeostasis [inference]

temperature homeostasis

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

astrocyte development

animal gross anatomical part developmental process [inference]

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

astrocyte development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to chemical [inference]

response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to oxygen-containing compound [inference]

response to catecholamine [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of potassium ion transport

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of potassium ion transport

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake [inference]

regulation of dopamine uptake involved in synaptic transmission

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of neuron migration

regulation of neuron migration [inference]

positive regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of potassium ion transport

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating dopamine receptor signaling pathway

G protein-coupled dopamine receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

presynaptic modulation of chemical synaptic transmission

regulation of metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of neuron migration

regulation of neuron migration [inference]

positive regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

regulation of synaptic plasticity [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	IEA
plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex

cellular anatomical structure [inference]

endomembrane system

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

non-motile cilium

9+0 non-motile cilium

neuron projection [inference]

dendrite

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

non-motile cilium

9+0 non-motile cilium

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

postsynapse [inference]

dendritic spine

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
heterotrimeric G-protein binding	IDA
dopamine binding	IMP
dopamine binding	IEA
arrestin family protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

dopamine binding

protein-containing complex binding [inference]

heterotrimeric G-protein binding

catecholamine binding [inference]

dopamine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity

dopamine neurotransmitter receptor activity, coupled via Gs

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1074	kidney failure	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	41726	FB:FBgn0011582
Xenopus laevis	108710578	Xenbase:XB-GENE-6500264
Mus musculus	13488	MGI:99578
Caenorhabditis elegans	180714	WB:WBGene00001052

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Last updated: April 6, 2026