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desmoglein 3

Summary

Gene Symbol

DSG3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1830

PubChem

1830

Alliance of Genome Resources

HGNC:3050

JoGo

DSG3

TogoVar

DSG3

Annotation

Keyword

3D-structure
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Cytoplasm
Glycoprotein
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal
Tight junction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P32926	130 kDa pemphigus vulgaris antigen Cadherin family member 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
desmosome assembly	IMP
actin filament organization	ISS
cell adhesion	IEA
homophilic cell-cell adhesion	IEA
negative regulation of cell migration	IMP

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

homophilic cell-cell adhesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

cell-cell junction organization [inference]

desmosome organization [inference]

desmosome assembly

cell-cell junction assembly [inference]

adherens junction organization [inference]

adherens junction assembly

tight junction organization [inference]

tight junction assembly

supramolecular fiber organization [inference]

actin filament organization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

regulation of protein localization to adherens junction [inference]

positive regulation of protein localization to adherens junction

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

positive regulation of protein localization to membrane

regulation of protein localization to membrane [inference]

positive regulation of protein localization to membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

positive regulation of protein localization to membrane

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of protein localization to membrane

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

positive regulation of protein localization to membrane

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of bicellular tight junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of protein localization to membrane

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of bicellular tight junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

positive regulation of protein localization to membrane

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cornified envelope	TAS
cornified envelope	IEA
cytoplasm	IDA
cytoplasm	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

cornified envelope

cell junction

anchoring junction

cell-cell junction

desmosome

tight junction

bicellular tight junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion binding	IBA
calcium ion binding	IEA
protein binding	IPI
protein dimerization activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

protein dimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Desmoglein-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 5** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Catenin binding domain superfamily
Desmosomal cadherin

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements