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MIRAGE

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide

Summary

Gene Symbol

P4ha2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18452

KEGG Gene ID

PubChem

18452

Alliance of Genome Resources

MGI:894286

Annotation

Keyword

Alternative splicing
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Proteomics identification
Reference proteome
Signal
TPR repeat
Vitamin C

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q5SX74
Q5SX75
Q3UQ81
Q60716	Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

primary metabolic process [inference]

amino acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA
endoplasmic reticulum lumen	IEA
cytosol	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

procollagen-proline 4-dioxygenase complex

catalytic complex [inference]

oxidoreductase complex [inference]

procollagen-proline 4-dioxygenase complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

1

2

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Last »
GO Term	Evidence Code	PMID
procollagen-proline 4-dioxygenase activity	ISO
procollagen-proline 4-dioxygenase activity	IDA
procollagen-proline 4-dioxygenase activity	IBA
procollagen-proline 4-dioxygenase activity	IEA
iron ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

dioxygenase activity

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prolyl 4-hydroxylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 6** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase alpha-subunit, N-terminal
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	176569	WB:WBGene00001077
Caenorhabditis elegans	178170	WB:WBGene00004025
Homo sapiens	8974	HGNC:8547

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026