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phosphodiesterase 1B, Ca2+-calmodulin dependent

Summary

Gene Symbol

Pde1b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18574

PubChem

18574

Alliance of Genome Resources

MGI:97523

Annotation

Keyword

Calmodulin-binding
Coiled coil
Cytoplasm
Hydrolase
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Zinc
cAMP
cGMP

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q01065	63 kDa Cam-PDE
Q9DBS6
A0A2I3BPC1
Q6PDS5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
response to amphetamine	IMP	17010100 17559891
response to amphetamine	IGI	17010100
signal transduction	IMP	12077213
signal transduction	IEA	http://purl.obolibrary.org/obo/go/references/0000002
locomotory behavior	IMP	12077213 17559891

GO Hierarchy

biological process

cellular process [inference]

signal transduction

metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

locomotory behavior

visual behavior [inference]

visual learning

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to macrophage colony-stimulating factor [inference]

cellular response to macrophage colony-stimulating factor stimulus

cellular response to cytokine stimulus [inference]

response to granulocyte macrophage colony-stimulating factor [inference]

cellular response to granulocyte macrophage colony-stimulating factor stimulus

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	ISS	http://purl.obolibrary.org/obo/go/references/0000024
cytosol	ISO	http://purl.obolibrary.org/obo/go/references/0000119
cytosol	IEA	http://purl.obolibrary.org/obo/go/references/0000044
neuronal cell body	ISO	http://purl.obolibrary.org/obo/go/references/0000096
neuronal cell body	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cyclic-nucleotide phosphodiesterase activity	ISO	9003415 http://purl.obolibrary.org/obo/go/references/0000096
3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000003
3',5'-cyclic-AMP phosphodiesterase activity	ISS	http://purl.obolibrary.org/obo/go/references/0000024
3',5'-cyclic-AMP phosphodiesterase activity	ISO	http://purl.obolibrary.org/obo/go/references/0000096 http://purl.obolibrary.org/obo/go/references/0000119
3',5'-cyclic-AMP phosphodiesterase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000116

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-GMP phosphodiesterase activity

binding [inference]

protein binding [inference]

calmodulin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
3',5'-cyclic-nucleotide phosphodiesterase activity
calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
hydrolase activity
metal ion binding

Displaying **all 6** entries
InterPro
3'5'-cyclic nucleotide phosphodiesterase N-terminal
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
3'5'-cyclic nucleotide phosphodiesterase, conserved site
3'5'-cyclic nucleotide phosphodiesterase
HD/PDEase domain