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phospholipase C, beta 3

Summary

Gene Symbol

Plcb3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18797

PubChem

18797

Alliance of Genome Resources

MGI:104778

Annotation

Keyword

Acetylation
Calcium
Coiled coil
Cytoplasm
Hydrolase
Lipid degradation
Membrane
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P51432	Phosphoinositide phospholipase C-beta-3 Phospholipase C-beta-3
Q8CI86

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of systemic arterial blood pressure	ISO	18468998
lipid metabolic process	IEA
post-Golgi vesicle-mediated transport	ISO	http://purl.obolibrary.org/obo/go/references/0000096
signal transduction	IEA
G protein-coupled receptor signaling pathway	ISO	http://purl.obolibrary.org/obo/go/references/0000096

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

intracellular signal transduction

phosphatidylinositol-mediated signaling

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

phosphatidylinositol metabolic process

phosphatidylinositol catabolic process

catabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

intercellular transport [inference]

release of sequestered calcium ion into cytosol

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

intercellular transport [inference]

release of sequestered calcium ion into cytosol

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

intracellular signal transduction

phosphatidylinositol-mediated signaling

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
nucleus	EXP	9714794
nucleus	IEA	http://purl.obolibrary.org/obo/go/references/0000044
nucleoplasm	ISO
nucleoplasm	IEA
cytoplasm	ISS	http://purl.obolibrary.org/obo/go/references/0000024

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

cytosol

postsynaptic cytosol

membrane

plasma membrane [inference]

sarcolemma

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

side of membrane [inference]

cytoplasmic side of membrane

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	ISS	http://purl.obolibrary.org/obo/go/references/0000024
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	ISO	http://purl.obolibrary.org/obo/go/references/0000096 http://purl.obolibrary.org/obo/go/references/0000119
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA	9188725
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000104 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000116 http://purl.obolibrary.org/obo/go/references/0000117

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

C-type glycerophospholipase activity [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

C-type glycerophospholipase activity [inference]

binding [inference]

protein binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular adaptor activity

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
lipid metabolic process
metal ion binding
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

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InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-beta, PH domain
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain
Phospholipase C, phosphatidylinositol-specific, Y domain