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Guidelines

MIRAGE

palmitoyl-protein thioesterase 1

Summary

Gene Symbol

Ppt1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19063

PubChem

19063

Alliance of Genome Resources

MGI:1298204

Annotation

Keyword

Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3U6W3	Palmitoyl-protein hydrolase 1
O88531	Palmitoyl-protein hydrolase 1
Q3TEL0	Palmitoyl-protein hydrolase 1
Q3U6J9	Palmitoyl-protein hydrolase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
protein depalmitoylation	ISS
protein depalmitoylation	ISO
protein depalmitoylation	IMP	11717424 16242638
endocytosis	IBA
receptor-mediated endocytosis	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule depalmitoylation [inference]

protein depalmitoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance catabolic process [inference]

macromolecule catabolic process

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular process [inference]

vesicle-mediated transport [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

membrane organization [inference]

membrane raft organization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

grooming behavior

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

system development [inference]

nervous system development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport [inference]

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

import into cell [inference]

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

neurotransmitter secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell growth

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell growth

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of biological quality [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

regulation of phospholipase A2 activity

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IBA
extracellular space	IDA	9685319
nucleus	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosolic region [inference]

presynaptic cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

membrane microdomain [inference]

membrane raft

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
protein binding	IPI	19941651
palmitoyl-(protein) hydrolase activity	ISS
palmitoyl-(protein) hydrolase activity	ISO
palmitoyl-(protein) hydrolase activity	IDA	12483688
palmitoyl-(protein) hydrolase activity	IMP	11717424 16242638

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

CoA hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

long-chain acyl-CoA hydrolase activity

palmitoyl hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

palmitoyl protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
macromolecule depalmitoylation
nervous system development
palmitoyl hydrolase activity
palmitoyl-(protein) hydrolase activity
receptor-mediated endocytosis

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Palmitoyl protein thioesterase

Rhea

H₂O

H⁺ + hexadecanoate

Enzyme

3.1.2.22

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110721	neuronal ceroid lipofuscinosis 1	Alliance of Genome Resources
DOID:0110731	neuronal ceroid lipofuscinosis 3	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003778
Gene Name: palmitoyl-protein thioesterase 1

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5538	Xenbase:XB-GENE-923070	HUMAN49061
Xenopus tropicalis	19063	Xenbase:XB-GENE-923070
Rattus norvegicus	29411	Xenbase:XB-GENE-923070	RATNO34701
Xenopus tropicalis	31805	Xenbase:XB-GENE-923070
Xenopus tropicalis	191744	Xenbase:XB-GENE-923070
Bos taurus	281421		BOVIN27228
Danio rerio	406648		DANRE16023
Pan troglodytes	456789		PANTR20750
Canis lupus familiaris	475316		CANLF03912
Macaca mulatta	693377		MACMU21827

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Last updated: August 4, 2025