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prosaposin

Summary

Gene Symbol

Psap

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19156

PubChem

19156

Alliance of Genome Resources

MGI:97783

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 9** entries
UniProt	Protein Name
Q61207	Sulfated glycoprotein 1
Q8BFQ1
Q3UE29	Sulfated glycoprotein 1
Q3UFE8	Sulfated glycoprotein 1
Q3TWM9	Sulfated glycoprotein 1
B2RUD7	Sulfated glycoprotein 1
Q3TXJ0	Sulfated glycoprotein 1
Q3UAS4
E9PZ00

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
NK T cell differentiation	IMP
corneocyte development	IMP
lipid metabolic process	IDA
lipid metabolic process	IEA
obsolete membrane lipid metabolic process

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

primary metabolic process [inference]

lipid metabolic process

sphingolipid metabolic process

ceramide metabolic process

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

galactolipid metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

galactolipid metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

epithelial cell differentiation [inference]

epithelial cell differentiation involved in prostate gland development

cell development [inference]

corneocyte development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

localization within membrane [inference]

ganglioside GM1 transport to membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

inclusion body assembly

membrane assembly [inference]

cornified envelope assembly

membrane organization [inference]

plasma membrane organization [inference]

cornified envelope assembly

membrane assembly [inference]

cornified envelope assembly

export from cell [inference]

secretion by cell [inference]

protein secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

system process [inference]

renal system process [inference]

micturition

excretion [inference]

micturition

nervous system process

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

locomotory behavior [inference]

walking behavior

organ growth [inference]

prostate gland growth

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure development [inference]

cell development [inference]

corneocyte development

cochlea development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

epithelial cell differentiation [inference]

epithelial cell differentiation involved in prostate gland development

cell development [inference]

corneocyte development

growth [inference]

developmental growth

organ growth [inference]

prostate gland growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

lipid transport [inference]

ceramide transport [inference]

ganglioside GM1 transport to membrane

glycolipid transport [inference]

ganglioside GM1 transport to membrane

protein transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

ganglioside GM1 transport to membrane

organic acid transport [inference]

carboxylic acid transport [inference]

ganglioside GM1 transport to membrane

secretion [inference]

secretion by cell [inference]

protein secretion

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

nitrogen compound transport [inference]

ceramide transport [inference]

ganglioside GM1 transport to membrane

export from cell [inference]

secretion by cell [inference]

protein secretion

carbohydrate derivative transport [inference]

glycolipid transport [inference]

ganglioside GM1 transport to membrane

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

localization within membrane [inference]

ganglioside GM1 transport to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	EXP
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

extracellular region

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	IPI
protease binding	ISO
protein binding	IPI
phospholipid binding	ISO
lipid binding	IEA

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

lipid antigen binding

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

scaffold protein binding

lipid binding

sphingolipid binding [inference]

glycosphingolipid binding [inference]

ganglioside binding [inference]

ceramide binding [inference]

ganglioside binding [inference]

glycolipid binding [inference]

glycosphingolipid binding [inference]

ganglioside binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

ganglioside GM3 binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

ganglioside GM3 binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding [inference]

ganglioside binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prosaposin

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
epithelial cell differentiation involved in prostate gland development
lipid metabolic process
prostate gland growth
regulation of lipid metabolic process
sphingolipid metabolic process

Displaying **all 6** entries
InterPro
Saposin A-type domain
Saposin B type domain
Saposin B type, region 2
Saposin-like type B, region 1
Saposin-like
Saposin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111330	combined saposin deficiency	Alliance of Genome Resources
DOID:10581	metachromatic leukodystrophy	Alliance of Genome Resources
DOID:10587	Krabbe disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements