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R-spondin 1

Summary

Gene Symbol

Rspo1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

192199

KEGG Gene ID

PubChem

192199

Alliance of Genome Resources

MGI:2183426

Annotation

Keyword

Disulfide bond
Glycoprotein
Heparin-binding
Nucleus
Reference proteome
Repeat
Secreted
Sensory transduction
Signal
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Z132	Cysteine-rich and single thrombospondin domain-containing protein 3 Roof plate-specific spondin-1
B1ASC1	Roof plate-specific spondin-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
positive regulation of protein phosphorylation	ISO
regulation of receptor internalization	ISO
regulation of receptor internalization	IEA
male meiotic nuclear division	IMP
regulation of gene expression	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cell cycle process [inference]

meiotic cell cycle process [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of non-canonical Wnt signaling pathway [inference]

positive regulation of non-canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of non-canonical Wnt signaling pathway [inference]

positive regulation of non-canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of non-canonical Wnt signaling pathway [inference]

positive regulation of non-canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of macromolecule metabolic process

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of cell population proliferation [inference]

regulation of germ cell proliferation [inference]

regulation of male germ cell proliferation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

negative regulation of behavior [inference]

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of feeding behavior [inference]

regulation of eating behavior [inference]

negative regulation of eating behavior

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of germ cell proliferation [inference]

regulation of male germ cell proliferation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space
nucleus	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	ISO
G protein-coupled receptor binding	IEA
signaling receptor binding	ISO
signaling receptor binding	IBA
signaling receptor binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

R-spondin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
heparin binding

Displaying **all 5** entries
InterPro
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
R-spondin, Fu-CRD domain
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat