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Guidelines

MIRAGE

eukaryotic translation initiation factor 2 subunit alpha

Summary

Gene Symbol

EIF2S1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1965

KEGG Gene ID

[""]

PubChem

1965

Alliance of Genome Resources

HGNC:3265

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Initiation factor
Mitochondrion
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Translation regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53XC0	Eukaryotic translation initiation factor 2 subunit alpha
P05198	Eukaryotic translation initiation factor 2 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
mitophagy	IDA
translational initiation	IDA
translational initiation	IBA
translational initiation	IEA
regulation of translational initiation	NAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

integrated stress response signaling [inference]

metabolic process [inference]

translational initiation

catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

stress granule assembly

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to kainic acid

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

response to nitrogen compound [inference]

response to kainic acid

response to oxygen-containing compound [inference]

response to kainic acid

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

integrated stress response signaling [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

regulation of type B pancreatic cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	ISS
cytoplasm	IEA
mitochondrion	IDA
mitochondrion	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2 complex

ribonucleoprotein complex [inference]

translation initiation ternary complex

cytosolic translation preinitiation complex [inference]

eukaryotic 48S preinitiation complex

cellular anatomical structure [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot [inference]

glial limiting end-foot

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
RNA binding	IEA
RNA binding	HDA
translation initiation factor activity	TAS
translation initiation factor activity	IDA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding

RNA binding

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

translation factor activity [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Translation initiation factor 2

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
IF2a, S1-like domain
Nucleic acid-binding, OB-fold
S1 domain
Translation initiation factor 2, alpha subunit, C-terminal
Translation initiation factor 2, alpha subunit, middle domain superfamily
Translation initiation factor 2, alpha subunit

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

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Last updated: April 6, 2026