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ubiquitin protein ligase E3 component n-recognin 1

Summary

Gene Symbol

UBR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

197131

KEGG Gene ID

PubChem

197131

Alliance of Genome Resources

HGNC:16808

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IWV7	N-recognin-1 Ubiquitin-protein ligase E3-alpha-1 Ubiquitin-protein ligase E3-alpha-I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein ubiquitination	IBA
protein ubiquitination	IEA
protein catabolic process	IEA
negative regulation of TOR signaling	IMP
negative regulation of TOR signaling	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein metabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-leucine

cellular response to nitrogen compound [inference]

cellular response to L-leucine

cellular response to oxygen-containing compound [inference]

cellular response to L-leucine

response to stimulus [inference]

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to L-leucine [inference]

cellular response to L-leucine

cellular response to amino acid stimulus [inference]

cellular response to L-leucine

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-leucine

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-leucine

cellular response to nitrogen compound [inference]

cellular response to L-leucine

cellular response to oxygen-containing compound [inference]

cellular response to L-leucine

response to nitrogen compound [inference]

response to L-leucine [inference]

cellular response to L-leucine

cellular response to nitrogen compound [inference]

cellular response to L-leucine

response to oxygen-containing compound [inference]

response to L-leucine [inference]

cellular response to L-leucine

cellular response to oxygen-containing compound [inference]

cellular response to L-leucine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-leucine

cellular response to nitrogen compound [inference]

cellular response to L-leucine

cellular response to oxygen-containing compound [inference]

cellular response to L-leucine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ubiquitin ligase complex	IBA
ubiquitin ligase complex	IEA
proteasome complex	IEA
cytoplasm	IBA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical structure [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	IEA
protein binding	IPI
zinc ion binding	IEA
ubiquitin protein ligase activity	IDA
ubiquitin protein ligase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

amino acid binding [inference]

L-leucine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-leucine binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

L-leucine binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-leucine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
metal ion binding
protein ubiquitination
transferase activity
ubiquitin-dependent protein catabolic process via the N-end rule pathway
zinc ion binding

Displaying **all 7** entries
InterPro
Adaptor protein ClpS, core
E3 ubiquitin-protein ligase ELL-like
E3 ubiquitin-protein ligase UBR-like, C-terminal
E3 ubiquitin-protein ligase UBR1-like
Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like
Winged helix DNA-binding domain superfamily
Zinc finger, UBR-type