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ALG14 UDP-N-acetylglucosaminyltransferase subunit

Summary

Gene Symbol

ALG14

Aliases

MGC19780

Organism

Homo sapiens (human)

External Links

NCBI Gene

199857

GGDB ID

gg202

HGNC

28287

mRNA

NM_144988

map

1p21.3

Protein

NP_659425

OMIM

612866

KEGG Gene ID

["hsa:199857"]

PubChem

199857

Alliance of Genome Resources

HGNC:28287

JoGo

ALG14

TogoVar

ALG14

Annotation

Keyword

Congenital myasthenic syndrome
Disease variant
Endoplasmic reticulum
Epilepsy
Intellectual disability
Neurodegeneration
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96F25	Asparagine-linked glycosylation 14 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA
dolichol-linked oligosaccharide biosynthetic process	IDA
dolichol-linked oligosaccharide biosynthetic process	IBA
dolichol-linked oligosaccharide biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	EXP
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IEA
UDP-N-acetylglucosamine transferase complex	IDA
UDP-N-acetylglucosamine transferase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

UDP-N-acetylglucosamine transferase complex

endoplasmic reticulum protein-containing complex [inference]

UDP-N-acetylglucosamine transferase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

UDP-N-acetylglucosamine transferase complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI
protein-membrane adaptor activity	IGI
protein-membrane adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

UDP-N-acetylglucosamine transferase subunit

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
dolichol-linked oligosaccharide biosynthetic process

Displaying 1 entry
InterPro
Oligosaccharide biosynthesis protein Alg14-like

Human Protein Atlas

ENSG00000172339

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg202

Gene Symbol

ALG14

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G68544GH		G05026ZL

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G68544GH		G05026ZL

Orthologous Gene

Displaying **all 5** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_500417	NM_068016
Mus musculus	NP_077140	NM_024178
Saccharomyces cerevisiae	NP_009626	X76294
Drosophila melanogaster	NP_573031	NM_132803
Rattus norvegicus	NP_001014198	NM_001014176

KEGG BRITE Database

Orthology

K07441

Name

beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.141]

References

16100110

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05970	2.4.1.141	G68544GH	G05026ZL

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110658	congenital myasthenic syndrome 15	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 71 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000218	High palate
HP:0000262	Turricephaly
HP:0000280	Coarse facial features
HP:0000303	Mandibular prognathia
HP:0000347	Micrognathia
HP:0000508	Ptosis
HP:0000581	Blepharophimosis
HP:0000717	Autism
HP:0000718	Aggressive behavior

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:619036	myopathy, epilepsy, and progressive cerebral atrophy
OMIM:616227	congenital myasthenic syndrome 15
OMIM:619031	intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies
ORPHA:353327	obsolete congenital myasthenic syndromes with glycosylation defect

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements