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Guidelines

MIRAGE

ATP binding cassette subfamily A member 1

Summary

Gene Symbol

ABCA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

19

KEGG Gene ID

PubChem

19

Alliance of Genome Resources

HGNC:29

Annotation

Keyword

3D-structure
ATP-binding
Atherosclerosis
Cell membrane
Cholesterol metabolism
Disease variant
Disulfide bond
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7XCW9
O95477	ATP-binding cassette sub-family A member 1 ATP-binding cassette transporter 1 Cholesterol efflux regulatory protein
B2RUU2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 59 in total

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GO Term	Evidence Code	PMID
response to nutrient	IEA
cholesterol metabolic process	IDA
protein secretion	ISS
protein secretion	IMP
protein secretion	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

apolipoprotein A-I-mediated signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

protein metabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

protein metabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vesicle-mediated transport [inference]

endosomal transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

vesicle organization [inference]

secretory granule organization [inference]

platelet dense granule organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

export from cell [inference]

secretion by cell [inference]

export across plasma membrane

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

response to fluid shear stress [inference]

response to laminar fluid shear stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to nutrient levels

response to nutrient

response to vitamin [inference]

response to vitamin B3

response to chemical [inference]

response to nutrient

response to vitamin [inference]

response to vitamin B3

response to xenobiotic stimulus

cellular response to xenobiotic stimulus

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to retinoic acid [inference]

cellular response to retinoic acid

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to retinoic acid [inference]

cellular response to retinoic acid

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

response to alcohol [inference]

response to cholesterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport [inference]

cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

lipid translocation [inference]

protein transport [inference]

organophosphate ester transport [inference]

phospholipid transport

peptide transport [inference]

peptide secretion

organic hydroxy compound transport

sterol transport [inference]

cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

vesicle-mediated transport [inference]

endosomal transport

secretion [inference]

peptide secretion

secretion by cell [inference]

intracellular transport [inference]

endosomal transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

transmembrane transport

nitrogen compound transport [inference]

sphingolipid translocation

export from cell [inference]

secretion by cell [inference]

export across plasma membrane

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of multicellular organismal process [inference]

positive regulation of high-density lipoprotein particle assembly

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

apolipoprotein A-I-mediated signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

regulation of lipid storage [inference]

regulation of cholesterol storage [inference]

negative regulation of cholesterol storage

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

regulation of high-density lipoprotein particle assembly

positive regulation of high-density lipoprotein particle assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

negative regulation of cellular process [inference]

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

regulation of high-density lipoprotein particle assembly

positive regulation of high-density lipoprotein particle assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of high-density lipoprotein particle assembly

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of high-density lipoprotein particle assembly

regulation of high-density lipoprotein particle assembly

positive regulation of high-density lipoprotein particle assembly

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
endosome	IDA
endosome	IEA
endoplasmic reticulum membrane	TAS
Golgi apparatus	IEA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

basolateral plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

endosome

endocytic vesicle

phagocytic vesicle

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle

cytoplasmic vesicle [inference]

endosome

endocytic vesicle

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle

cytoplasmic vesicle [inference]

endosome

endocytic vesicle

phagocytic vesicle

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	IPI
protein binding	IPI
ATP binding	IDA
ATP binding	IEA
obsolete phospholipid transporter activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

macromolecule transmembrane transporter activity [inference]

transmembrane protein transporter activity

lipid transfer activity [inference]

phospholipid transfer activity

sterol transfer activity [inference]

cholesterol transfer activity

intramembrane lipid carrier activity [inference]

phosphatidylcholine intramembrane carrier activity [inference]

phosphatidylcholine floppase activity

sphingolipid intramembrane carrier activity [inference]

sphingolipid floppase activity

ATPase-coupled intramembrane lipid carrier activity

floppase activity

protein transporter activity [inference]

transmembrane protein transporter activity

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding

signaling receptor binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

ATPase binding

apolipoprotein binding

apolipoprotein A-I binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

phospholipid binding [inference]

phosphatidylcholine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

phosphatidylcholine binding

alcohol binding [inference]

cholesterol binding

quaternary ammonium group binding [inference]

phosphatidylcholine binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

high-density lipoprotein particle binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cargo receptor activity [inference]

apolipoprotein receptor activity [inference]

apolipoprotein A-I receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

apolipoprotein A-I receptor activity

molecular carrier activity [inference]

lipid carrier activity [inference]

lipid transfer activity [inference]

phospholipid transfer activity

sterol transfer activity [inference]

cholesterol transfer activity

intramembrane lipid carrier activity [inference]

phosphatidylcholine intramembrane carrier activity [inference]

phosphatidylcholine floppase activity

sphingolipid intramembrane carrier activity [inference]

sphingolipid floppase activity

ATPase-coupled intramembrane lipid carrier activity

floppase activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid carrier activity

floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-binding cassette sub-family a

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:0080957	primary hypoalphalipoproteinemia 1	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:1387	hypolipoproteinemia	Alliance of Genome Resources
DOID:1388	Tangier disease	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11303	MGI:99607
Caenorhabditis elegans	171782	WB:WBGene00000020

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026