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primase and DNA directed polymerase

Summary

Gene Symbol

PRIMPOL

Organism

Homo sapiens (human)

External Links

NCBI Gene

201973

KEGG Gene ID

PubChem

201973

Alliance of Genome Resources

HGNC:26575

Annotation

Keyword

3D-structure
Alternative splicing
Chromosome
Coiled coil
DNA repair
DNA-directed DNA polymerase
DNA-directed RNA polymerase
Disease variant
Manganese
Metal-binding
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A5S6SZ32
Q96LW4	Coiled-coil domain-containing protein 111

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
DNA-templated DNA replication	IEA
mitochondrial DNA replication	IMP
mitochondrial DNA replication	IBA
mitochondrial DNA replication	IEA
DNA replication, synthesis of primer	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

mitochondrial DNA replication

DNA repair [inference]

mitochondrial DNA repair

DNA damage tolerance [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

mitochondrial DNA replication

DNA repair [inference]

mitochondrial DNA repair

DNA damage tolerance [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis

error-prone translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

mitochondrial DNA repair

DNA damage tolerance [inference]

translesion synthesis

error-prone translesion synthesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

R-loop processing

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

mitochondrial DNA repair

DNA damage tolerance [inference]

translesion synthesis

error-prone translesion synthesis

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

mitochondrial DNA repair

DNA damage tolerance [inference]

translesion synthesis

error-prone translesion synthesis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
DNA-directed RNA polymerase complex
nucleus	IDA
nucleus	IBA
nucleus	IEA
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

chromosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
chromatin binding	IDA
chromatin binding	IBA
DNA-directed DNA polymerase activity	IDA
DNA-directed DNA polymerase activity	IBA
DNA-directed DNA polymerase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity

DNA-directed DNA polymerase activity

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

DNA-directed RNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity

DNA-directed DNA polymerase activity

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

DNA-directed RNA polymerase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna-directed primase/polymerase protein

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
Gene Ontology
DNA replication, synthesis of RNA primer
chromatin binding
error-prone translesion synthesis
mitochondrial DNA replication
response to UV
translesion synthesis