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macrophage scavenger receptor 1

Summary

Gene Symbol

Msr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20288

PubChem

20288

Alliance of Genome Resources

MGI:98257

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Collagen
Disulfide bond
Endocytosis
Glycoprotein
LDL
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P30204	Macrophage acetylated LDL receptor I and II Scavenger receptor type A
Q8CED7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
receptor-mediated endocytosis	IGI	22438044
phagocytosis, engulfment	IGI	22438044
negative regulation of gene expression	IMP	11240025
positive regulation of macrophage derived foam cell differentiation	IGI	12376530
positive regulation of cholesterol storage	IMP	12376530

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

multicellular organismal process [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport

protein transport [inference]

lipoprotein transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

nitrogen compound transport [inference]

protein transport [inference]

lipoprotein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of localization [inference]

regulation of lipid storage [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of cholesterol storage [inference]

positive regulation of cholesterol storage

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

Displaying **all 5** entries
GO Term	Evidence Code	PMID
collagen trimer	IEA
plasma membrane	TAS
plasma membrane	IMP	11240025
membrane
low-density lipoprotein particle	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	IGI	11240025
amyloid-beta binding	IBA
scavenger receptor activity	IEA
low-density lipoprotein particle binding	IMP	12376530
low-density lipoprotein particle binding	IBA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

low-density lipoprotein particle binding

cargo receptor activity

scavenger receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysyl oxidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
collagen fibril organization
copper ion binding
metal ion binding
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
oxidoreductase activity