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Guidelines

MIRAGE

serine (or cysteine) peptidase inhibitor, clade F, member 1

Summary

Gene Symbol

Serpinf1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20317

PubChem

20317

Alliance of Genome Resources

MGI:108080

Annotation

Keyword

3D-structure
Direct protein sequencing
Glycoprotein
Phosphoprotein
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P97298	Caspin Serpin F1 Stromal cell-derived factor 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
kidney development	IEA
short-term memory	ISO
short-term memory	IEA
response to acidic pH	IEA
negative regulation of endothelial cell migration	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to metal ion [inference]

cellular response to cobalt ion

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

short-term memory

behavior [inference]

learning or memory [inference]

memory [inference]

short-term memory

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

retina development in camera-type eye

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

rhythmic process [inference]

ovulation cycle

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to metal ion [inference]

response to cobalt ion [inference]

cellular response to cobalt ion

cellular response to metal ion [inference]

cellular response to cobalt ion

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to arsenic-containing substance

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to metal ion [inference]

cellular response to cobalt ion

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

response to peptide

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to retinoic acid [inference]

cellular response to retinoic acid

response to ketone [inference]

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to metal ion [inference]

cellular response to cobalt ion

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of developmental process [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of reproductive process [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

negative regulation of developmental process [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

regulation of epithelial cell proliferation involved in prostate gland development [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of reproductive process [inference]

negative regulation of reproductive process [inference]

negative regulation of epithelial cell proliferation involved in prostate gland development

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix [inference]

basement membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

axon hillock

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IBA
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor),

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
negative regulation of angiogenesis
positive regulation of neurogenesis
serine-type endopeptidase inhibitor activity

Displaying **all 7** entries
InterPro
Pigment epithelium derived factor, serpin domain
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110350	osteogenesis imperfecta type 6	Alliance of Genome Resources

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Last updated: April 6, 2026