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Guidelines

MIRAGE

sel-1 suppressor of lin-12-like (C. elegans)

Summary

Gene Symbol

Sel1l

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20338

PubChem

20338

Alliance of Genome Resources

MGI:1329016

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Notch signaling pathway
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6GTY4	Suppressor of lin-12-like protein 1
Q9Z2G6	Suppressor of lin-12-like protein 1
Q5DTL8	Suppressor of lin-12-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IMP
Notch signaling pathway
protein secretion	IMP
protein transport	IEA
retrograde protein transport, ER to cytosol	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

intercellular transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

ERAD pathway

export from cell [inference]

secretion by cell [inference]

protein secretion

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

ERAD pathway

response to chemical [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

ERAD pathway

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein secretion

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein secretion

secretion [inference]

secretion by cell [inference]

protein secretion

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
Hrd1p ubiquitin ligase complex	ISO
Hrd1p ubiquitin ligase complex	IEA
Hrd1p ubiquitin ligase ERAD-L complex	ISS
Hrd1p ubiquitin ligase ERAD-L complex	ISO
Hrd1p ubiquitin ligase ERAD-L complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex

Derlin-1 retrotranslocation complex

endoplasmic reticulum protein-containing complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex

Derlin-1 retrotranslocation complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cytoplasmic ubiquitin ligase complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cytoplasmic ubiquitin ligase complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

endoplasmic reticulum quality control compartment

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein sel-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ERAD pathway

Displaying **all 2** entries
InterPro
Sel1-like repeat
Tetratricopeptide-like helical domain superfamily

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026