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Guidelines

MIRAGE

erythrocyte membrane protein band 4.2

Summary

Gene Symbol

EPB42

Organism

Homo sapiens (human)

External Links

NCBI Gene

2038

PubChem

2038

Alliance of Genome Resources

HGNC:3381

JoGo

EPB42

TogoVar

EPB42

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell shape
Cytoskeleton
Direct protein sequencing
Disease variant
Erythrocyte maturation
Hereditary hemolytic anemia
Myristate
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P16452	Erythrocyte membrane protein band 4.2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
cell morphogenesis
cytoskeleton organization	IEA
regulation of cell shape
peptide cross-linking	IBA
hemoglobin metabolic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process

protein modification process [inference]

peptide cross-linking

cellular developmental process [inference]

cell maturation [inference]

erythrocyte maturation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

erythrocyte maturation

anatomical structure development [inference]

animal organ development [inference]

hematopoietic or lymphoid organ development [inference]

spleen development

cellular developmental process [inference]

cell maturation [inference]

erythrocyte maturation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
cytoskeleton	TAS
cytoskeleton	IEA
plasma membrane	TAS
plasma membrane	IEA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

ankyrin-1 complex

cellular anatomical structure [inference]

plasma membrane

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cortical cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cortical cytoskeleton

cell periphery

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein-glutamine gamma-glutamyltransferase activity	IBA
protein-glutamine gamma-glutamyltransferase activity	IEA
structural constituent of cytoskeleton	TAS
protein binding	IPI
ATP binding	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

protein-glutamine gamma-glutamyltransferase activity

catalytic activity, acting on a protein [inference]

protein-glutamine gamma-glutamyltransferase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transglutaminase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
metal ion binding
protein-glutamine gamma-glutamyltransferase activity

Displaying **all 9** entries
InterPro
Immunoglobulin E-set
Immunoglobulin-like fold
Papain-like cysteine peptidase superfamily
Protein-glutamine gamma-glutamyltransferase, animal
Transglutaminase, C-terminal domain superfamily
Transglutaminase, C-terminal
Transglutaminase, N-terminal
Transglutaminase-like superfamily
Transglutaminase-like

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110920	hereditary spherocytosis type 5	Alliance of Genome Resources
DOID:12971	hereditary spherocytosis	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026