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dematin actin binding protein

Summary

Gene Symbol

DMTN

Organism

Homo sapiens (human)

External Links

NCBI Gene

2039

PubChem

2039

Alliance of Genome Resources

HGNC:3382

JoGo

DMTN

TogoVar

DMTN

Annotation

Keyword

3D-structure
Actin capping
Actin-binding
Alternative splicing
Cell membrane
Cell projection
Cytoskeleton
Direct protein sequencing
Disulfide bond
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Tumor suppressor

Proteins

Displaying 1 entry
UniProt	Protein Name
Q08495	Dematin actin-binding protein Erythrocyte membrane protein band 4.9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
cytoskeleton organization	TAS
cytoskeleton organization	IEA
regulation of cell shape	IMP
regulation of cell shape	IEA
regulation of lamellipodium assembly	IMP

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization

endoplasmic reticulum organization [inference]

endoplasmic reticulum tubular network organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

protein-containing complex organization [inference]

protein-containing complex assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

smooth endoplasmic reticulum calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

smooth endoplasmic reticulum calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

smooth endoplasmic reticulum calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

smooth endoplasmic reticulum calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

smooth endoplasmic reticulum calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

smooth endoplasmic reticulum calcium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to membrane [inference]

negative regulation of protein targeting to membrane

negative regulation of establishment of protein localization [inference]

negative regulation of protein targeting to membrane

regulation of cellular localization [inference]

regulation of protein targeting to membrane [inference]

negative regulation of protein targeting to membrane

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein targeting to membrane

negative regulation of establishment of protein localization [inference]

negative regulation of protein targeting to membrane

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

positive regulation of wound healing

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

regulation of peptidyl-threonine phosphorylation [inference]

negative regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

regulation of peptidyl-threonine phosphorylation [inference]

negative regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

regulation of peptidyl-threonine phosphorylation [inference]

negative regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell-substrate adhesion

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein targeting to membrane

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium organization [inference]

regulation of lamellipodium assembly

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cellular localization [inference]

regulation of protein targeting to membrane [inference]

negative regulation of protein targeting to membrane

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

regulation of biological quality [inference]

regulation of cell shape

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

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GO Term	Evidence Code	PMID
cytoplasm	IEA
smooth endoplasmic reticulum	IEA
cytosol	TAS
cytosol	IDA
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

platelet dense tubular network membrane

plasma membrane region [inference]

cell projection membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membraneless organelle [inference]

cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

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GO Term	Evidence Code	PMID
actin binding	IDA
actin binding	IEA
signaling receptor binding	IDA
protein binding	IPI
spectrin binding	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

spectrin binding

protein-containing complex binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

actin filament-associated protein 1-like protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
actin binding
actin filament binding
cytoskeleton organization
lamellipodium assembly

Displaying 1 entry
InterPro
Villin headpiece

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements