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solute carrier family 12, member 1

Summary

Gene Symbol

Slc12a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20495

PubChem

20495

Alliance of Genome Resources

MGI:103150

Annotation

Keyword

Alternative splicing
Cell membrane
Chloride
Glycoprotein
Phosphoprotein
Potassium transport
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P55014	BSC1 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 Kidney-specific Na-K-Cl symporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 21 in total

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GO Term	Evidence Code	PMID
sodium ion transmembrane transport	IBA
chloride ion homeostasis	IBA
potassium ion homeostasis	IBA
sodium ion homeostasis	IBA
positive regulation of calcineurin-NFAT signaling cascade

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

urea transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

monoatomic anion homeostasis [inference]

chloride ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

hyperosmotic salinity response [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

response to salt stress [inference]

hyperosmotic salinity response [inference]

cellular hyperosmotic salinity response

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

hyperosmotic salinity response [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

response to salt stress [inference]

hyperosmotic salinity response [inference]

cellular hyperosmotic salinity response

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hyperosmotic salinity response

cellular hyperosmotic response [inference]

cellular hyperosmotic salinity response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

urea transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

organic substance transport [inference]

one-carbon compound transport [inference]

urea transport [inference]

urea transmembrane transport

nitrogen compound transport [inference]

amide transport [inference]

urea transport [inference]

urea transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into membrane from inner side

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell surface	ISO
apical plasma membrane	ISO
apical plasma membrane	IDA	11423561 15550389 29993276
apical plasma membrane	IBA
extracellular exosome	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
potassium ion transmembrane transporter activity
chloride:monoatomic cation symporter activity

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 12 member

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell volume homeostasis
chloride ion homeostasis
chloride transmembrane transport
chloride
monoatomic ion transport
potassium ion homeostasis

Displaying **all 3** entries
InterPro
Amino acid permease/ SLC12A domain
SLC12A transporter family
SLC12A transporter, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110142	Bartter disease type 1	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 95 in total

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Species	Gene ID	Orthologous MAtrix
Pan troglodytes	453410	PANTR10255
Canis lupus familiaris	478292	CANLF12492
Macaca mulatta	714289	MACMU41009
Monodelphis domestica	100025723	MONDO02283
Ornithorhynchus anatinus	100090924	ORNAN26066
Sus scrofa	100154291	PIGXX14384
Pongo abelii	100173185	PONAB09054
Taeniopygia guttata	100228327	TAEGU02533
Oryctolagus cuniculus	100328575	RABIT06083
Callithrix jacchus	100414428	CALJA00767

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements