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Guidelines

MIRAGE

solute carrier family 22 (organic cation transporter), member 2

Summary

Gene Symbol

Slc22a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20518

KEGG Gene ID

PubChem

20518

Alliance of Genome Resources

MGI:1335072

Annotation

Keyword

Alternative splicing
Cell membrane
Glycoprotein
Ion transport
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O70577	Organic cation transporter 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 64 in total

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GO Term	Evidence Code	PMID
monoatomic cation transport	IDA
neurotransmitter transport	ISO
neurotransmitter transport	IEA
serotonin transport	ISS
serotonin transport	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export across plasma membrane

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

export from cell [inference]

export across plasma membrane

cellular detoxification

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

neurotransmitter transport

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

lipid transport [inference]

fatty acid transport [inference]

prostaglandin transport

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

organic cation transport

norepinephrine transport

norepinephrine uptake

thiamine transport [inference]

thiamine transmembrane transport

organic anion transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

icosanoid transport [inference]

prostaglandin transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

icosanoid transport [inference]

prostaglandin transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

organic hydroxy compound transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

xenobiotic transport

xenobiotic transport across blood-brain barrier

vitamin transport [inference]

thiamine transport [inference]

thiamine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

transmembrane transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export across plasma membrane

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

nitrogen compound transport [inference]

quaternary ammonium group transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

amine transport

monoamine transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

polyamine transport [inference]

putrescine transport

thiamine transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

histamine transport

histamine uptake

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

sulfur compound transport [inference]

thiamine transport [inference]

thiamine transmembrane transport

import into cell [inference]

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export from cell [inference]

export across plasma membrane

acetate ester transport [inference]

acetylcholine transport

establishment of localization in cell [inference]

neurotransmitter reuptake [inference]

serotonin uptake

detoxification [inference]

cellular detoxification

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
basal plasma membrane	ISS
basal plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

cholinergic synapse

Displaying entries **1 - 5** of 48 in total

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GO Term	Evidence Code	PMID
amine transmembrane transporter activity	ISO
amine transmembrane transporter activity	IEA
acetylcholine transmembrane transporter activity	ISS
acetylcholine transmembrane transporter activity	ISO
acetylcholine transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

amine transmembrane transporter activity

neurotransmitter transmembrane transporter activity

acetylcholine transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

basic amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-arginine transmembrane transporter activity

polyamine transmembrane transporter activity [inference]

putrescine transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleoside transmembrane transporter activity [inference]

pyrimidine nucleoside transmembrane transporter activity

toxin transmembrane transporter activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity

xenobiotic transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity

L-arginine transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

lipid transmembrane transporter activity [inference]

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

acetate ester transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

azole transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleoside transmembrane transporter activity [inference]

pyrimidine nucleoside transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

binding [inference]

lipid binding [inference]

steroid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Solute carrier family 22 member 22

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	29503	RGD:61936
Caenorhabditis elegans	172841	WB:WBGene00003842
Drosophila melanogaster	36417	FB:FBgn0033778
Drosophila melanogaster	35334	FB:FBgn0032879
Homo sapiens	6582	HGNC:10966
Saccharomyces cerevisiae S288C	850462	SGD:S000000695

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026