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Submissions

solute carrier family 2 (facilitated glucose transporter), member 4

Summary

Gene Symbol

Slc2a4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20528

KEGG Gene ID

PubChem

20528

Alliance of Genome Resources

MGI:95758

Annotation

Keyword

Cell membrane
Cytoplasm
Diabetes mellitus
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P14142	GT2 Glucose transporter type 4, insulin-responsive

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
learning or memory	ISO
short-term memory	ISO
long-term memory	ISO
amylopectin biosynthetic process	IDA
positive regulation of brain-derived neurotrophic factor receptor signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

carbohydrate derivative biosynthetic process [inference]

amylopectin biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

amylopectin metabolic process [inference]

amylopectin biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

amylopectin biosynthetic process

amylopectin metabolic process [inference]

amylopectin biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

D-glucose transmembrane transport

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to osmotic stress [inference]

cellular response to osmotic stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to hypoxia

response to abiotic stimulus [inference]

response to osmotic stress [inference]

cellular response to osmotic stress

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to alcohol [inference]

response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

D-glucose transmembrane transport

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

organic anion transport [inference]

dehydroascorbic acid transport

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

D-glucose transmembrane transport

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

import into cell [inference]

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

glucose import in response to insulin stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of synaptic vesicle budding from presynaptic endocytic zone membrane

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
cytoplasm	IEA
endosome	ISO
endosome	IDA
endosome	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

sarcolemma

clathrin-coated pit

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane

membrane microdomain [inference]

membrane raft

T-tubule

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome [inference]

multivesicular body

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome [inference]

multivesicular body

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome [inference]

multivesicular body

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

presynapse

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GO Term	Evidence Code	PMID
insulin-responsive D-glucose:proton symporter activity	TAS
protein binding	IPI
D-glucose uniporter activity	ISS
D-glucose uniporter activity	ISO
D-glucose uniporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

solute:proton symporter activity [inference]

carbohydrate:proton symporter activity [inference]

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

carbohydrate:proton symporter activity [inference]

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

solute:proton symporter activity [inference]

carbohydrate:proton symporter activity [inference]

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

carbohydrate:proton symporter activity [inference]

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

hexose uniporter activity [inference]

D-glucose uniporter activity

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

D-glucose transmembrane transporter activity

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

D-glucose uniporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

uniporter activity [inference]

hexose uniporter activity [inference]

D-glucose uniporter activity

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

carbohydrate:proton symporter activity [inference]

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

solute:proton symporter activity [inference]

carbohydrate:proton symporter activity [inference]

hexose:proton symporter activity [inference]

D-glucose:proton symporter activity [inference]

insulin-responsive D-glucose:proton symporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 2 (facilitated glucose

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hexose transmembrane transporter activity

Displaying **all 6** entries
InterPro
Glucose transporter GLUT
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25139	RGD:2711
Drosophila melanogaster	38109	FB:FBgn0264574
Homo sapiens	6517	HGNC:11009
Saccharomyces cerevisiae S288C	852543	SGD:S000000445

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements