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Guidelines

MIRAGE

spectrin beta, non-erythrocytic 1

Summary

Gene Symbol

Sptbn1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20742

KEGG Gene ID

PubChem

20742

Alliance of Genome Resources

MGI:98388

Annotation

Keyword

3D-structure
Acetylation
Actin capping
Actin-binding
Alternative splicing
Calmodulin-binding
Cell membrane
Coiled coil
Cytoskeleton
Glycoprotein
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q8BQ35
Q3TZN6	Beta-II spectrin Fodrin beta chain
Q3TTX2
Q8R1C2
Q62261	Beta-II spectrin Embryonic liver fodrin Fodrin beta chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	ISO
mitotic cytokinesis	IEA
plasma membrane organization	ISO
plasma membrane organization	IEA
central nervous system development	ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

actin filament-based process [inference]

actin cytoskeleton organization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

membrane assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

membrane organization [inference]

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

central nervous system formation

anatomical structure development [inference]

system development [inference]

central nervous system development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane

Golgi to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction

regulation of localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

positive regulation of interleukin-2 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

positive regulation of interleukin-2 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

positive regulation of interleukin-2 production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-2 production

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
nucleus	IEA
nucleolus	ISO
nucleolus	IEA
cytoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex

spectrin

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

cortical cytoskeleton

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

cortical cytoskeleton

cortical actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

postsynapse

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
structural constituent of cytoskeleton	ISS
structural constituent of cytoskeleton	ISO
structural constituent of cytoskeleton	IEA
protein binding	IPI

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin filament binding

ankyrin binding

enzyme binding [inference]

GTPase binding

lipid binding [inference]

phospholipid binding

protein-containing complex binding

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

spectrin, beta, non-erythrocytic 1

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
actin binding
actin cytoskeleton organization
actin filament binding
actin filament capping
cytoskeleton organization
phospholipid binding
structural constituent of cytoskeleton

Displaying **all 10** entries
InterPro
Actinin-type actin-binding domain, conserved site
CH domain superfamily
Calponin homology domain
PH-like domain superfamily
Pleckstrin homology domain 9
Pleckstrin homology domain, spectrin-type
Pleckstrin homology domain
Spectrin repeat
Spectrin, beta subunit
Spectrin/alpha-actinin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5572	Beckwith-Wiedemann syndrome	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	6711	HGNC:11275

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Last updated: April 6, 2026