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suppressor of Ty 5, DSIF elongation factor subunit

Summary

Gene Symbol

Supt5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20924

KEGG Gene ID

PubChem

20924

Alliance of Genome Resources

MGI:1202400

Annotation

Keyword

Acetylation
Activator
Alternative splicing
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome
Repeat
Repressor
Transcription regulation
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O55201	DRB sensitivity-inducing factor large subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
negative regulation of transcription by RNA polymerase II	ISO
negative regulation of transcription by RNA polymerase II	IEA
DNA-templated transcription elongation	IEA
regulation of transcription by RNA polymerase II	IEA
transcription elongation by RNA polymerase II	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription elongation

transcription elongation by RNA polymerase II

transcription pausing by RNA polymerase II

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of DNA-templated transcription elongation

negative regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of DNA-templated transcription elongation

negative regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of DNA-templated transcription elongation

negative regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of DNA-templated transcription elongation

negative regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of DNA-templated transcription elongation

negative regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

regulation of DNA-templated transcription elongation

negative regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription elongation by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IEA
nucleoplasm	ISO
nucleoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

transcription elongation factor complex [inference]

DSIF complex

cellular anatomical structure [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chromatin binding	IDA
mRNA binding	IBA
enzyme binding	ISO
enzyme binding	IEA
protein heterodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

chromatin binding

protein binding [inference]

enzyme binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

RNA polymerase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

RNA polymerase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transcription elongation factor

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
regulation of DNA-templated transcription elongation
transcription elongation by RNA polymerase II
transcription elongation-coupled chromatin remodeling

Displaying entries **1 - 10** of 16 in total

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InterPro
KOW
Large ribosomal subunit protein uL2, domain 2
NGN domain, eukaryotic
NGN domain
NusG, N-terminal domain superfamily
NusG-like, N-terminal
Spt5 C-terminal domain
Spt5 transcription elongation factor, N-terminal
Spt5, KOW domain repeat 1
Spt5, KOW domain repeat 2

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	6829	HGNC:11469
Saccharomyces cerevisiae S288C	854999	SGD:S000004470

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements