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Guidelines

MIRAGE

ATP binding cassette subfamily A member 2

Summary

Gene Symbol

ABCA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

20

KEGG Gene ID

PubChem

20

Alliance of Genome Resources

HGNC:32

Annotation

Keyword

ATP-binding
Alternative splicing
Disease variant
Endosome
Epilepsy
Glycoprotein
Intellectual disability
Lysosome
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BZC7	ATP-binding cassette transporter 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
ganglioside metabolic process	ISS
lipid metabolic process	NAS
sphingomyelin metabolic process	ISS
glycosphingolipid metabolic process	ISS
lipid transport	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

primary metabolic process [inference]

lipid metabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process

sphingomyelin metabolic process

glycosphingolipid metabolic process

ganglioside metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process

ganglioside metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

carbohydrate derivative metabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process

ganglioside metabolic process

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly [inference]

central nervous system myelin formation

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

sphingolipid translocation [inference]

ceramide translocation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

behavior [inference]

locomotory behavior

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly [inference]

central nervous system myelin formation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular sphingolipid homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular sphingolipid homeostasis

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

intracellular sphingolipid homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to xenobiotic stimulus

response to hormone [inference]

response to steroid hormone

response to lipid [inference]

response to sterol [inference]

response to cholesterol

response to steroid hormone

response to oxygen-containing compound [inference]

response to sterol [inference]

response to cholesterol

response to alcohol [inference]

response to cholesterol

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

lipid translocation [inference]

sphingolipid translocation [inference]

ceramide translocation

ceramide transport [inference]

ceramide translocation

vascular transport [inference]

transport across blood-brain barrier

transmembrane transport

nitrogen compound transport [inference]

ceramide transport [inference]

ceramide translocation

sphingolipid translocation [inference]

ceramide translocation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

negative regulation of cholesterol efflux

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

negative regulation of cholesterol efflux

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cholesterol efflux

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process

negative regulation of steroid metabolic process

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of amyloid precursor protein catabolic process

positive regulation of amyloid-beta formation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

sphingolipid translocation [inference]

ceramide translocation

Displaying entries **11 - 15** of 19 in total

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GO Term	Evidence Code	PMID
endosome membrane	IDA
endosome membrane	IEA
membrane	NAS
membrane	IDA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical structure [inference]

microtubule organizing center

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleotide binding	NAS
lipid carrier activity	IBA
protein binding	IPI
ATP binding	ISS
ATP binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

intramembrane lipid carrier activity [inference]

sphingolipid intramembrane carrier activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

ATPase-coupled intramembrane lipid carrier activity [inference]

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

peptidase regulator activity [inference]

endopeptidase regulator activity

molecular carrier activity [inference]

lipid carrier activity

intramembrane lipid carrier activity [inference]

sphingolipid intramembrane carrier activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

ATPase-coupled intramembrane lipid carrier activity [inference]

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid carrier activity [inference]

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-binding cassette sub-family a

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11305	MGI:99606
Rattus norvegicus	79248	RGD:620238
Caenorhabditis elegans	171782	WB:WBGene00000020

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Last updated: April 6, 2026