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exostosin like glycosyltransferase 2

Summary

Gene Symbol

EXTL2

Aliases

alpha-1,4-N-acteylhexosaminyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2135

GGDB ID

gg161

HGNC

3516

mRNA

NM_001439

map

1p21

Protein

NP_001430

OMIM

602411

KEGG Gene ID

hsa:2135

PubChem

2135

Alliance of Genome Resources

HGNC:3516

JoGo

EXTL2

TogoVar

EXTL2

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Manganese
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9UBQ6	Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 Alpha-GalNAcT EXTL2 EXT-related protein 2 Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
F5GZK1
Q8N8F1	Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 Alpha-GalNAcT EXTL2 EXT-related protein 2 Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
N-acetylglucosamine metabolic process	IDA
N-acetylglucosamine metabolic process	IEA
heparan sulfate proteoglycan biosynthetic process	IEA
UDP-N-acetylgalactosamine metabolic process	IDA
UDP-N-acetylgalactosamine metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

carbohydrate derivative metabolic process

amino sugar metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
extracellular region	IEA
nucleoplasm
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
acetylglucosaminyltransferase activity	IEA
glycosyltransferase activity	IEA
manganese ion binding	IEA
alpha-1,4-N-acetylgalactosaminyltransferase activity	IDA
alpha-1,4-N-acetylgalactosaminyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity [inference]

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

manganese ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000162694

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg161

Gene Symbol

EXTL2

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_067363	NM_021388
Rattus norvegicus	XP_227614	XM_227614

Rhea

RHEA:16221

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.223

PMID

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	58193	MGI:1889574
Rattus norvegicus	310803	RGD:1307684
Danio rerio	558373	ZFIN:ZDB-GENE-060929-1122
Xenopus laevis	443929	Xenbase:XB-GENE-6251526
Xenopus tropicalis	493327	Xenbase:XB-GENE-1001404

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

International Collaboration

Acknowledgements