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MIRAGE

proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

Summary

Gene Symbol

Psmd2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21762

PubChem

21762

Alliance of Genome Resources

MGI:1096584

Annotation

Keyword

Acetylation
Phosphoprotein
Proteasome
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8VDM4	26S proteasome regulatory subunit RPN1 26S proteasome regulatory subunit S2 26S proteasome subunit p97
Q3TKV1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
regulation of protein catabolic process	IEA
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
regulation of AMPA receptor activity	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of AMPA receptor activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of AMPA receptor activity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of transmembrane transporter activity [inference]

regulation of AMPA receptor activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
proteasome complex	ISO
proteasome complex	IDA
proteasome complex	IEA
nucleus	IBA
proteasome regulatory particle	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

proteasome storage granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membraneless organelle [inference]

proteasome storage granule

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI
enzyme regulator activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

26S proteasome non-ATPase regulatory subunit

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying 1 entry
Gene Ontology
proteasome-mediated ubiquitin-dependent protein catabolic process

Displaying **all 6** entries
InterPro
26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
Armadillo-like helical
Armadillo-type fold
Proteasome/cyclosome repeat
RPN1, N-terminal

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026