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MIRAGE
acyl-CoA synthetase long chain family member 4
Summary
- Gene Symbol
-
- ACSL4
- Aliases
-
- ACS4
- LACS4
- lignoceroyl-CoA synthase
- long-chain fatty-acid-Coenzyme A ligase 4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Alport syndrome
- Alternative splicing
- Cell membrane
- Deafness
- Disease variant
- Elliptocytosis
- Fatty acid metabolism
- Intellectual disability
- Ligase
- Magnesium
- Microsome
- Mitochondrion outer membrane
- Nucleotide-binding
- Peroxisome
- Phosphoprotein
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| long-chain fatty acid metabolic process | ||
| long-chain fatty acid metabolic process | ||
| long-chain fatty acid metabolic process | ||
| long-chain fatty acid metabolic process | ||
| lipid metabolic process |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
organonitrogen compound metabolic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
purine-containing compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm | ||
| mitochondrion | ||
| mitochondrial outer membrane | ||
| peroxisomal membrane | ||
| endoplasmic reticulum |
| GO Term | Evidence Code | PMID |
|---|---|---|
| long-chain fatty acid-CoA ligase activity | ||
| long-chain fatty acid-CoA ligase activity | ||
| long-chain fatty acid-CoA ligase activity | ||
| ATP binding | ||
| very long-chain fatty acid-CoA ligase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- long chain acyl-coA synthetase
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ligase activity |
| InterPro |
|---|
| AMP-binding, conserved site |
| AMP-dependent synthetase/ligase domain |
| ANL, N-terminal domain |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112050 | non-syndromic X-linked intellectual disability 63 | |
| DOID:1059 | intellectual disability |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001643 | Patent ductus arteriosus |
| HP:0001646 | Abnormal aortic valve morphology |
| HP:0002907 | Microscopic hematuria |
| HP:0004445 | Elliptocytosis |
| HP:0005280 | Depressed nasal bridge |
| HP:0010864 | Intellectual disability, severe |
| HP:0011069 | Supernumerary tooth |
| HP:0011463 | Childhood onset |
| HP:0012471 | Thick vermilion border |
| HP:0100820 | Glomerulopathy |
| Disease ID | Disease Name |
|---|---|
| OMIM:300387 |
|
| ORPHA:86818 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP002158
- Gene Name
- acyl-CoA synthetase long-chain family member 4
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 103036866 | ASTMX04624 | ||
| 103123708 | ERIEU07770 | ||
| 103178869 | CALMI02055 | ||
| 103275588 | CARSF08475 | ||
| 103679743 | URSMA24158 | ||
| 103750023 | NANGA03749 | ||
| 103816373 | SERCA10834 | ||
| 104674335 | RHIRO40033 | ||
| 105490468 | MACNE33673 | ||
| 105542820 | MANLE11041 |
