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FA complementation group B

Summary

Gene Symbol

FANCB

Organism

Homo sapiens (human)

External Links

NCBI Gene

2187

PubChem

2187

Alliance of Genome Resources

HGNC:3583

JoGo

FANCB

TogoVar

FANCB

Annotation

Keyword

3D-structure
Acetylation
DNA repair
Fanconi anemia
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
C9J5X9
Q8NB91	Fanconi anemia-associated polypeptide of 95 kDa
A0A8Q3WL66

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
interstrand cross-link repair	NAS	19965384
positive regulation of double-strand break repair via homologous recombination	IBA
replication-born double-strand break repair via sister chromatid exchange	IBA
negative regulation of double-strand break repair via homologous recombination	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

interstrand cross-link repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

interstrand cross-link repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

interstrand cross-link repair

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin	IDA	22343915
nucleoplasm	TAS
cytosol	TAS
Fanconi anaemia nuclear complex	NAS	22343915
Fanconi anaemia nuclear complex	IDA	20347428

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

Fanconi anaemia nuclear complex

cellular anatomical structure [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	17396147

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fanconi anemia group b protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
interstrand cross-link repair
negative regulation of double-strand break repair via homologous recombination
positive regulation of double-strand break repair via homologous recombination
replication-born double-strand break repair via sister chromatid exchange

Displaying 1 entry
InterPro
Fanconi anemia group B protein

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111098	Fanconi anemia complementation group B	Alliance of Genome Resources
DOID:5520	head and neck squamous cell carcinoma	Alliance of Genome Resources