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fibroblast activation protein alpha

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

2191

PubChem

2191

Alliance of Genome Resources

HGNC:3590

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Apoptosis
Cell adhesion
Cell junction
Cell membrane
Cell projection
Cleavage on pair of basic residues
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DLR2
Q12884	170 kDa melanoma membrane-bound gelatinase Dipeptidyl peptidase FAP Fibroblast activation protein alpha Gelatine degradation protease FAP Integral membrane serine protease Post-proline cleaving enzyme Serine integral membrane protease Surface-expressed protease

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **16 - 16** of 16 in total

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GO Term	Evidence Code	PMID
negative regulation of extracellular matrix organization	IDA	10455171

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

cellular process [inference]

cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

melanocyte apoptotic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

melanocyte proliferation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cell cycle

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
focal adhesion	HDA	21423176
cell surface	ISS
membrane	NAS	9065413
lamellipodium	IDA	16651416 9065413
lamellipodium membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protease binding	IPI	17317851
endopeptidase activity	IDA	17317851
serine-type endopeptidase activity	IDA	10593948
integrin binding	IPI	10455171
protein binding	IPI	16651416 21314817

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
dipeptidyl-peptidase activity
proteolysis
serine-type peptidase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Dipeptidylpeptidase IV, N-terminal domain
Peptidase S9, prolyl oligopeptidase, catalytic domain

Ortholog

Displaying entries **71 - 79** of 79 in total

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Species	Gene ID	Orthologous MAtrix
Vulpes vulpes	112916465	VULVU09042
Pseudonaja textilis	113434122	PSETE04793
Bos indicus x Bos taurus	113903304	BOBOX37985
Vombatus ursinus	114045792	VOMUR03253
Corvus moneduloides	116446572	CORMO25033
Rhinolophus ferrumequinum	117025799	RHIFE13705
Balaenoptera musculus	118898204	BALMU00261
Panthera leo	122227832	PANLE11094
Ursus americanus	123781330	URSAM01218

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OrthoDB (Group)

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Acknowledgements