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Guidelines

MIRAGE

flap structure-specific endonuclease 1

Summary

Gene Symbol

FEN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2237

KEGG Gene ID

PubChem

2237

Alliance of Genome Resources

HGNC:3650

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Coiled coil
DNA repair
DNA replication
Direct protein sequencing
Endonuclease
Exonuclease
Magnesium
Metal-binding
Methylation
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P39748	DNase IV Flap structure-specific endonuclease 1 Maturation factor 1
Q6FHX6	Flap structure-specific endonuclease 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	TAS
DNA replication	TAS
DNA repair	TAS
base-excision repair	IEA
base-excision repair, gap-filling	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cell cycle process [inference]

telomere maintenance via semi-conservative replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

UV protection

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion [inference]

positive regulation of sister chromatid cohesion

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion [inference]

positive regulation of sister chromatid cohesion

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleoplasm	IDA
nucleoplasm	IEA
nucleolus	IDA
nucleolus	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IBA
magnesium ion binding	IEA
DNA binding	IMP
DNA binding	IEA
damaged DNA binding	TAS

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

exonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

5'-3' exonuclease activity

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

RNA-DNA hybrid ribonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

RNA-DNA hybrid ribonuclease activity

exonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

5'-3' exonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

RNA-DNA hybrid ribonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

RNA-DNA hybrid ribonuclease activity

binding [inference]

nucleic acid binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

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Gene Ontology
5'-3' exonuclease activity
5'-flap endonuclease activity
DNA repair
DNA replication, removal of RNA primer
base-excision repair
catalytic activity
endonuclease activity
hydrolase activity, acting on ester bonds
hydrolase activity
magnesium ion binding

Displaying **all 8** entries
InterPro
5'-3' exonuclease, C-terminal domain superfamily
Flap endonuclease 1
Helix-hairpin-helix motif, class 2
PIN-like domain superfamily
XPG conserved site
XPG, N-terminal
XPG-I domain
XPG/Rad2 endonuclease

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026