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Guidelines

MIRAGE

aldehyde dehydrogenase 3 family member A2

Summary

Gene Symbol

ALDH3A2

Aliases

FALDH
fatty aldehyde dehydrogenase

Organism

Homo sapiens (human)

External Links

NCBI Gene

224

HGNC

403

KEGG Gene ID

hsa:224

PubChem

224

Alliance of Genome Resources

HGNC:403

JoGo

ALDH3A2

TogoVar

ALDH3A2

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Fatty acid metabolism
Ichthyosis
Intellectual disability
Microsome
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51648	Aldehyde dehydrogenase 10 Fatty aldehyde dehydrogenase Microsomal aldehyde dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
aldehyde metabolic process	NAS
aldehyde metabolic process	IDA
aldehyde metabolic process	IBA
aldehyde metabolic process	IEA
fatty acid metabolic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process

hexadecanal metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

sesquiterpenoid metabolic process

diterpenoid metabolic process [inference]

phytol metabolic process

fatty acid derivative metabolic process [inference]

fatty alcohol metabolic process [inference]

phytol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

phytol metabolic process

fatty alcohol metabolic process [inference]

phytol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

system development [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
peroxisome	IDA
peroxisomal membrane	TAS
peroxisomal membrane	IEA
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
3-chloroallyl aldehyde dehydrogenase activity	IBA
aldehyde dehydrogenase (NAD+) activity	EXP
aldehyde dehydrogenase (NAD+) activity	IDA
aldehyde dehydrogenase (NAD+) activity	IMP
aldehyde dehydrogenase (NAD+) activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [inference]

long-chain-alcohol oxidase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

3-chloroallyl aldehyde dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

fatty aldehyde dehydrogenase (NAD+) activity

farnesal dehydrogenase (NAD+) activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000072210

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00128

Name

aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]

References

Rhea

acetaldehyde + H₂O + NAD⁺

H⁺ + acetate + NADH

Enzyme

1.2.1.3

PMID

H₂O + an aldehyde + NAD⁺

H⁺ + a carboxylate + NADH

Enzyme

PMID

H₂O + (2E,6E)-farnesal + NAD⁺

H⁺ + NADH + (2E,6E)-farnesoate

Enzyme

1.2.1.94

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14501	Sjogren-Larsson syndrome	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 42 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000483	Astigmatism
HP:0000488	Retinopathy
HP:0000545	Myopia
HP:0000551	Color vision defect
HP:0000608	Macular degeneration
HP:0000613	Photophobia
HP:0000682	Abnormal dental enamel morphology
HP:0000958	Dry skin

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:816	Sjogren-Larsson syndrome
OMIM:270200	Sjogren-Larsson syndrome

PubChem Disease

GHR Health Conditions

Sjögren-Larsson syndrome

MedGen Diseases

Sjögren-Larsson syndrome

OMIM Phenotypes

SJOGREN-LARSSON SYNDROME; SLS

KEGG Diseases

Sjogren-Larsson syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000042
Gene Name: aldehyde dehydrogenase 3 family, member A2

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026