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Guidelines

MIRAGE

tubulin, beta 4B class IVB

Summary

Gene Symbol

Tubb4b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

227613

KEGG Gene ID

PubChem

227613

Alliance of Genome Resources

MGI:1915472

Annotation

Keyword

3D-structure
Acetylation
Cytoskeleton
Direct protein sequencing
Flagellum
GTP-binding
Isopeptide bond
Magnesium
Metal-binding
Microtubule
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P68372	Tubulin beta-2C chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA
mitotic cell cycle	IBA
microtubule-based process	NAS
microtubule-based process	IEA
flagellated sperm motility	IDA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process

microtubule cytoskeleton organization

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

cell cycle [inference]

mitotic cell cycle

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

Displaying entries **1 - 5** of 13 in total

1

2

3

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoskeleton	IEA
microtubule	ISO
microtubule	IBA
microtubule	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

tubulin complex

cellular anatomical structure [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

membraneless organelle [inference]

intracellular membraneless organelle [inference]

spindle [inference]

mitotic spindle

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

spindle [inference]

mitotic spindle

microtubule cytoskeleton

intercellular bridge

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

cytoplasmic microtubule [inference]

axonemal microtubule

Displaying entries **1 - 5** of 9 in total

1

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GO Term	Evidence Code	PMID
double-stranded RNA binding	ISO
double-stranded RNA binding	IEA
GTPase activity	IEA
structural constituent of cytoskeleton	IBA
structural constituent of cytoskeleton	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
GTP binding
cytoskeleton organization
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 8** entries
InterPro
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	10383	HGNC:20771

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026