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Guidelines

MIRAGE

MAP-kinase activating death domain

Summary

Gene Symbol

Madd

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

228355

KEGG Gene ID

PubChem

228355

Alliance of Genome Resources

MGI:2444672

Annotation

Keyword

Alternative splicing
Apoptosis
Cell membrane
Cell projection
Cytoplasm
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A2AGR0	Rab3 GDP/GTP exchange factor Rab3 GDP/GTP exchange protein
A0A0R4J1F4	Rab3 GDP/GTP exchange factor Rab3 GDP/GTP exchange protein
E9QN47	Rab3 GDP/GTP exchange factor Rab3 GDP/GTP exchange protein
Q80U28	Rab3 GDP/GTP exchange factor Rab3 GDP/GTP exchange protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
apoptotic process
regulation of Rab protein signal transduction	ISO
regulation of Rab protein signal transduction	IBA
regulation of apoptotic process	ISO
regulation of apoptotic process	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

cell death [inference]

programmed cell death [inference]

apoptotic process

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

execution phase of apoptosis

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of pancreatic amylase secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of pancreatic amylase secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of pancreatic amylase secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of programmed cell death [inference]

regulation of apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of cell cycle

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of pancreatic amylase secretion [inference]

negative regulation of pancreatic amylase secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of protein secretion [inference]

negative regulation of pancreatic amylase secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

negative regulation of growth hormone secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of growth hormone secretion

Displaying entries **1 - 5** of 12 in total

1

2

3

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Last »
GO Term	Evidence Code	PMID
cytoplasm	IEA
cytosol	ISO
cytosol	IBA
plasma membrane	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

cytosol

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISO
guanyl-nucleotide exchange factor activity	IBA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	32442	FB:FBgn0030613
Homo sapiens	8567	HGNC:6766

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Last updated: April 6, 2026