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sterile alpha and TIR motif containing 1

Summary

Gene Symbol

SARM1

Aliases

KIAA0524
SAMD2
SARM

Organism

Homo sapiens (human)

External Links

NCBI Gene

23098

HGNC

17074

KEGG Gene ID

PubChem

23098

Alliance of Genome Resources

HGNC:17074

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Cytoplasm
Differentiation
Hydrolase
Innate immunity
Mitochondrion
NAD
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Synapse
Transit peptide

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q0D2N8	NADP(+) hydrolase SARM1 Sterile alpha and TIR motif-containing protein 1
Q05B42	NADP(+) hydrolase SARM1 Sterile alpha and TIR motif-containing protein 1
Q6SZW1	NADP(+) hydrolase SARM1 Sterile alpha and Armadillo repeat protein Sterile alpha and TIR motif-containing protein 1 Sterile alpha motif domain-containing protein 2 Tir-1 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
signal transduction	IEA
nervous system development
response to glucose
NAD+ catabolic process	IDA
NAD+ catabolic process	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure

multicellular organismal process [inference]

system process [inference]

nervous system process

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to wounding [inference]

response to axon injury

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to chemical [inference]

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendrite morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of neuron apoptotic process

positive regulation of programmed cell death

positive regulation of cellular process [inference]

positive regulation of programmed cell death

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of synapse organization [inference]

regulation of synapse pruning

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISS
cytoplasm	EXP
cytoplasm	IDA
cytoplasm	IEA
mitochondrion	EXP

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
double-stranded DNA binding	IDA
NAD+ nucleosidase activity	IDA
NAD+ nucleosidase activity	IEA
protein binding	IPI
signaling adaptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding

protein binding

identical protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sterile alpha and TIR motif-containing protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
NAD+ nucleosidase activity
hydrolase activity
negative regulation of MyD88-independent toll-like receptor signaling pathway
response to axon injury
signaling adaptor activity

Displaying **all 7** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Sterile alpha and TIR motif-containing protein 1
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Rhea

RHEA:16301

H₂O + NAD⁺

H⁺ + nicotinamide + ADP-D-ribose

Enzyme

PMID

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	237868	MGI:2136419
Rattus norvegicus	287545	RGD:1310078
Caenorhabditis elegans	175502	WB:WBGene00006575
Drosophila melanogaster	38895	FB:FBgn0262579
Danio rerio	403143	ZFIN:ZDB-GENE-040219-1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements