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glucosidase II alpha subunit

Summary

Gene Symbol

GANAB

Aliases

G2AN
GIIA
GluII
KIAA0088
neutral alpha-glucosidase AB

Organism

Homo sapiens (human)

External Links

NCBI Gene

23193

HGNC

4138

KEGG Gene ID

["hsa:23193"]

PubChem

23193

Alliance of Genome Resources

HGNC:4138

JoGo

GANAB

TogoVar

GANAB

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosidase
Golgi apparatus
Phosphoprotein
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 6** entries
UniProt	Protein Name
B4DIW2	Alpha-glucosidase 2 Glucosidase II subunit alpha
Q14697	Alpha-glucosidase 2 Glucosidase II subunit alpha
B4DZ53	Alpha-glucosidase 2 Glucosidase II subunit alpha
B4DSM6	Alpha-glucosidase 2 Glucosidase II subunit alpha
E9PKU7	Alpha-glucosidase 2 Glucosidase II subunit alpha
F5H6X6	Alpha-glucosidase 2 Glucosidase II subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
N-glycan processing	IDA
N-glycan processing	IBA
N-glycan processing	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	EXP
endoplasmic reticulum	IDA
endoplasmic reticulum	IEA
endoplasmic reticulum lumen	NAS
endoplasmic reticulum lumen	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

glucosidase II complex

catalytic complex [inference]

glucosidase complex [inference]

glucosidase II complex

cellular anatomical structure [inference]

membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
protein binding	IPI
carbohydrate binding	IEA
glucan 1,3-alpha-glucosidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

glucosidase activity [inference]

alpha-glucosidase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucosidase, alpha

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
alpha-glucosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 7** entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase family 31, N-terminal domain
Glycoside hydrolase family 31, TIM barrel domain
Glycoside hydrolase superfamily
Glycosyl hydrolase family 31, C-terminal domain
Glycosyl hydrolase, all-beta
Glycosyl hydrolases family 31, active site

Human Protein Atlas

ENSG00000089597

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05546

Name

mannosyl-oligosaccharide alpha-1,3-glucosidase [EC:3.2.1.207]

References

10929008

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05980	3.2.1.207	G18948TG	G19958IL
R05981	3.2.1.207	G19958IL	G60230HH

Rhea

RHEA:56000

H₂O

β-D-glucose

Enzyme

3.2.1.207

PMID

RHEA:55996

H₂O

β-D-glucose

Enzyme

3.2.1.207

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050770	polycystic liver disease	Alliance of Genome Resources
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0110860	polycystic kidney disease 3	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 32 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000010	Recurrent urinary tract infections
HP:0000083	Renal insufficiency
HP:0000105	Enlarged kidney
HP:0000107	Renal cyst
HP:0000113	Polycystic kidney dysplasia
HP:0000790	Hematuria
HP:0000791	Uric acid nephrolithiasis
HP:0000822	Hypertension
HP:0001407	Hepatic cysts