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NEDD4 like E3 ubiquitin protein ligase

Summary

Gene Symbol

NEDD4L

Organism

Homo sapiens (human)

External Links

NCBI Gene

23327

KEGG Gene ID

PubChem

23327

Alliance of Genome Resources

HGNC:7728

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Differentiation
Direct protein sequencing
Disease variant
Endosome
Golgi apparatus
Host-virus interaction
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B7Z2P9
B7Z6K0
Q96PU5	HECT-type E3 ubiquitin transferase NED4L NEDD4.2 Nedd4-2
A0A1B0GVY1	HECT-type E3 ubiquitin transferase NED4L

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
regulation of membrane depolarization	IDA
ubiquitin-dependent protein catabolic process	IDA
ubiquitin-dependent protein catabolic process	IBA
ubiquitin-dependent protein catabolic process	IEA
protein monoubiquitination	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

receptor metabolic process [inference]

receptor catabolic process

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell differentiation

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

developmental process [inference]

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic ion transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

transmembrane transport [inference]

monoatomic ion transmembrane transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

regulation of transport [inference]

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

regulation of potassium ion export across plasma membrane [inference]

negative regulation of potassium ion export across plasma membrane

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

negative regulation of sodium ion transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

regulation of potassium ion export across plasma membrane [inference]

negative regulation of potassium ion export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

regulation of potassium ion export across plasma membrane [inference]

negative regulation of potassium ion export across plasma membrane

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of caveolin-mediated endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of dendrite morphogenesis

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

regulation of potassium ion export across plasma membrane [inference]

negative regulation of potassium ion export across plasma membrane

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion export across plasma membrane

negative regulation of sodium ion transmembrane transport

negative regulation of sodium ion import across plasma membrane

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of caveolin-mediated endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of synapse organization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of caveolin-mediated endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of membrane repolarization

regulation of biological quality [inference]

regulation of protein stability

regulation of membrane potential

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction [inference]

ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
cytoplasm	EXP
cytoplasm	IBA
cytoplasm	IEA
multivesicular body	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
potassium channel inhibitor activity	IDA
potassium channel inhibitor activity	IEA
sodium channel inhibitor activity	IDA
sodium channel inhibitor activity	IBA
sodium channel inhibitor activity	IEA