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Guidelines

MIRAGE

SET domain containing 1A

Summary

Gene Symbol

Setd1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

233904

PubChem

233904

Alliance of Genome Resources

MGI:2446244

Annotation

Keyword

Activator
Chromatin regulator
Chromosome
Cytoplasm
DNA damage
Methyltransferase
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
S-adenosyl-L-methionine
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
E9PYH6	SET domain-containing protein 1A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
brain development	ISO
brain development	IMP
positive regulation of gene expression	IMP
stem cell population maintenance	IMP
methylation

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

methylation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

multicellular organismal process [inference]

stem cell population maintenance

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

maintenance of cell number [inference]

stem cell population maintenance

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

regulation of stem cell proliferation [inference]

positive regulation of stem cell proliferation

regulation of neural precursor cell proliferation [inference]

positive regulation of neural precursor cell proliferation

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of cellular component organization [inference]

regulation of chromatin organization

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
chromatin	ISO
euchromatin	IDA
nucleus	ISO
nucleus	IDA
nucleus	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

histone methyltransferase complex

Set1C/COMPASS complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex

Set1C/COMPASS complex

cellular anatomical structure [inference]

euchromatin

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosome

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
RNA binding	ISS
RNA binding	ISO
RNA binding	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

histone methyltransferase activity [inference]

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

catalytic activity, acting on a protein [inference]

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

histone methyltransferase activity [inference]

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

histone modifying activity [inference]

histone methyltransferase activity [inference]

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 monomethyltransferase activity

binding [inference]

nucleic acid binding

RNA binding

protein binding

beta-catenin binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

histone-lysine n-methyltransferase

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
histone H3K4 methyltransferase activity
methylation
transferase activity

Displaying **all 9** entries
InterPro
COMPASS complex Set1 subunit, N-SET domain
Histone-lysine N-methyltransferase SETD1A/B-like, SET domain
Histone-lysine N-methyltransferase Set1-like
Nucleotide-binding alpha-beta plait domain superfamily
Post-SET domain
RNA recognition motif domain
RNA-binding domain superfamily
SET domain superfamily
SET domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5419	schizophrenia	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026