GlyCosmos Portal

Submissions

exosome component 2

Summary

Gene Symbol

EXOSC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23404

KEGG Gene ID

[""]

PubChem

23404

Alliance of Genome Resources

HGNC:17097

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Deafness
Disease variant
Dwarfism
Exonuclease
Exosome
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Retinitis pigmentosa
rRNA processing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KQW2
Q13868	Exosome component 2 Ribosomal RNA-processing protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
nuclear-transcribed mRNA catabolic process	IBA
rRNA processing	TAS
RNA processing	IDA
RNA catabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

rRNA metabolic process [inference]

rRNA processing

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA 3'-end processing [inference]

U4 snRNA 3'-end processing

sno(s)RNA metabolic process [inference]

sno(s)RNA processing [inference]

sno(s)RNA 3'-end processing [inference]

poly(A)-dependent snoRNA 3'-end processing

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

rRNA metabolic process [inference]

rRNA processing

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA 3'-end processing [inference]

U4 snRNA 3'-end processing

sno(s)RNA metabolic process [inference]

sno(s)RNA processing [inference]

sno(s)RNA 3'-end processing [inference]

poly(A)-dependent snoRNA 3'-end processing

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

CUT catabolic process

RNA processing

rRNA processing

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA processing [inference]

snRNA 3'-end processing [inference]

U4 snRNA 3'-end processing

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

sno(s)RNA 3'-end processing [inference]

poly(A)-dependent snoRNA 3'-end processing

snRNA 3'-end processing [inference]

U4 snRNA 3'-end processing

sno(s)RNA processing [inference]

sno(s)RNA 3'-end processing [inference]

poly(A)-dependent snoRNA 3'-end processing

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

positive regulation of cellular process [inference]

positive regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying entries **1 - 5** of 22 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
nuclear exosome (RNase complex)	NAS
nuclear exosome (RNase complex)	IDA
nuclear exosome (RNase complex)	IBA
cytoplasmic exosome (RNase complex)	NAS
cytoplasmic exosome (RNase complex)	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear exosome (RNase complex)

nucleolar exosome (RNase complex)

catalytic complex [inference]

exoribonuclease complex [inference]

exosome (RNase complex)

nuclear exosome (RNase complex)

nucleolar exosome (RNase complex)

cytoplasmic exosome (RNase complex)

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
3'-5'-RNA exonuclease activity	TAS
RNA binding	IBA
RNA binding	IEA
exonuclease activity
RNA exonuclease activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity

RNA exonuclease activity

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity

RNA exonuclease activity

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

binding [inference]

nucleic acid binding [inference]

RNA binding

7S RNA binding

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Exosome complex

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 8** entries
Gene Ontology
CUT catabolic process
U4 snRNA 3'-end processing
exonucleolytic catabolism of deadenylated mRNA
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
polyadenylation-dependent snoRNA 3'-end processing

Displaying **all 6** entries
InterPro
Exosome complex RNA-binding protein 1/RRP40/RRP4
Exosome complex component, N-terminal domain
K Homology domain, type 1 superfamily
K Homology domain, type 1
Nucleic acid-binding, OB-fold
RRP4, S1 domain