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solute carrier family 35 member A3

Summary

Gene Symbol

SLC35A3

Aliases

UDP-N-acetylglucosamine transporter

Organism

Homo sapiens (human)

External Links

NCBI Gene

23443

GGDB ID

gg174

HGNC

11023

mRNA

NM_012243

map

1p21

Protein

NP_036375

OMIM

605632

KEGG Gene ID

["hsa:23443"]

PubChem

23443

Alliance of Genome Resources

HGNC:11023

JoGo

SLC35A3

TogoVar

SLC35A3

Annotation

Keyword

Alternative splicing
Antiport
Autism spectrum disorder
Disease variant
Epilepsy
Golgi apparatus
Intellectual disability
Proteomics identification
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A1W2PR66
A0A1W2PQL8
Q9Y2D2	Golgi UDP-GlcNAc transporter Solute carrier family 35 member A3
A0A1W2PSD1
A0A1W2PRT7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
UDP-N-acetylglucosamine metabolic process	TAS
organophosphate ester transport	IEA
nucleobase-containing compound transport	IEA
transmembrane transport	IBA
UDP-galactose transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

transmembrane transport

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

organic anion transport [inference]

organophosphate ester transport

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport

transmembrane transport

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport

carbohydrate derivative transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Golgi membrane	EXP
Golgi membrane	TAS
Golgi membrane	IDA
Golgi membrane	IBA
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
UDP-galactose transmembrane transporter activity	IBA
UDP-galactose transmembrane transporter activity	IEA
UDP-N-acetylglucosamine transmembrane transporter activity	TAS
protein binding	IPI
pyrimidine nucleotide-sugar transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organophosphate ester transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CMP-sialic acid transporter

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
UDP-galactose transmembrane transporter activity
organic substance transport
pyrimidine nucleotide-sugar transmembrane transporter activity

Displaying 1 entry
InterPro
Nucleotide-sugar transporter

Human Protein Atlas

ENSG00000117620

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg174

Gene Symbol

SLC35A3

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_493723	NM_061322
Mus musculus	NP_659151	NM_144902
Rattus norvegicus	NP_001012082	NM_001012082

KEGG BRITE Database

Orthology

K15272

Name

solute carrier family 35 (UDP-sugar transporter), member A1/2/3

References

12759756

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 22 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000308	Microretrognathia
HP:0000729	Autistic behavior
HP:0001249	Intellectual disability
HP:0001256	Intellectual disability, mild
HP:0001263	Global developmental delay
HP:0001290	Generalized hypotonia
HP:0001385	Hip dysplasia
HP:0001765	Hammertoe