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Guidelines

MIRAGE

single-strand-selective monofunctional uracil-DNA glycosylase 1

Summary

Gene Symbol

SMUG1

Aliases

FDG
HMUDG
UNG3

Organism

Homo sapiens (human)

External Links

NCBI Gene

23583

HGNC

17148

KEGG Gene ID

PubChem

23583

Alliance of Genome Resources

HGNC:17148

Annotation

Keyword

Alternative splicing
DNA repair
DNA-binding
Direct protein sequencing
Hydrolase
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q53HV7
A0A024RAZ8
A0A0S2Z526
D6RI04

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
base-excision repair	IDA
base-excision repair	IEA
depyrimidination	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

organophosphate catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

organophosphate catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

carbohydrate derivative catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

macromolecule metabolic process [inference]

macromolecule modification [inference]

DNA modification [inference]

depyrimidination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depyrimidination

DNA modification [inference]

depyrimidination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depyrimidination

DNA modification [inference]

depyrimidination

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

carbohydrate derivative metabolic process [inference]

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

carbohydrate derivative catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

depyrimidination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

Displaying entry **6 - 6** of 6 in total

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1

2
GO Term	Evidence Code	PMID
cytosol

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IBA
DNA binding
uracil DNA N-glycosylase activity	IDA
uracil DNA N-glycosylase activity	IBA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

single-strand selective uracil DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

single-strand selective uracil DNA N-glycosylase activity

binding [inference]

nucleic acid binding [inference]

DNA binding

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	71726	MGI:1918976
Rattus norvegicus	315344	RGD:631403
Xenopus laevis	399139	Xenbase:XB-GENE-953126

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026