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ALK receptor tyrosine kinase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

238

KEGG Gene ID

PubChem

238

Alliance of Genome Resources

HGNC:427

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Chromosomal rearrangement
Disease variant
Disulfide bond
Glycoprotein
Phosphoprotein
Proteomics identification
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0K2YUJ3
B6D4Y2
Q9UM73	Anaplastic lymphoma kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
response to stress
signal transduction	TAS
cell surface receptor protein tyrosine kinase signaling pathway	IDA
cell surface receptor protein tyrosine kinase signaling pathway	IBA
cell surface receptor protein tyrosine kinase signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

cellular developmental process [inference]

cell development [inference]

neuron development

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

swimming behavior

adult behavior

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

anatomical structure development [inference]

hippocampus development

cell development [inference]

neuron development

system development [inference]

nervous system development

cellular developmental process [inference]

cell development [inference]

neuron development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

response to stimulus [inference]

response to stress

response to external stimulus [inference]

response to environmental enrichment

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of dopamine receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of dendrite development

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of dopamine receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of neuron differentiation

regulation of dendrite development [inference]

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of dendrite development

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of dopamine receptor signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of primary metabolic process

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of neuron differentiation

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of dendrite development [inference]

positive regulation of dendrite development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
protein-containing complex	IDA
signaling receptor complex	IBA
extracellular exosome	HDA

GO Hierarchy

cellular component

protein-containing complex

signaling receptor complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein tyrosine kinase activity	EXP
protein tyrosine kinase activity	TAS
protein tyrosine kinase activity	IDA
protein tyrosine kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

receptor signaling protein tyrosine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

receptor signaling protein tyrosine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

receptor signaling protein tyrosine kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

receptor signaling protein tyrosine kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tyrosine kinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
nucleotide binding
protein phosphorylation
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying **all 6** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain