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tumor necrosis factor (ligand) superfamily, member 13b

Summary

Gene Symbol

Tnfsf13b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

24099

KEGG Gene ID

PubChem

24099

Alliance of Genome Resources

MGI:1344376

Annotation

Keyword

Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3KP92
Q8BVA3
Q9WU72	B-cell-activating factor BAFF
A0A0U5J6R6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
B cell homeostasis	IMP
lymphocyte homeostasis	IBA
transitional one stage B cell differentiation	IMP
positive regulation of germinal center formation	IMP
immune response	IMP

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis

B cell homeostasis

immune response

lymphocyte costimulation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

B cell activation

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

B cell activation

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

B cell activation

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis

B cell homeostasis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

skin development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis

B cell homeostasis

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of immune response

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of germinal center formation [inference]

positive regulation of germinal center formation

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of developmental process [inference]

positive regulation of germinal center formation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of immune response

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of germinal center formation [inference]

positive regulation of germinal center formation

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of germinal center formation [inference]

positive regulation of germinal center formation

positive regulation of developmental process [inference]

positive regulation of germinal center formation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
perinuclear region of cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IBA
cytokine activity	IEA
tumor necrosis factor receptor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

tumor necrosis factor receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	10673	HGNC:11929

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements