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MIRAGE

ATP citrate lyase

Summary

Gene Symbol

Acly

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24159

KEGG Gene ID

PubChem

24159

Alliance of Genome Resources

RGD:2018

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Isopeptide bond
Lipid biosynthesis
Lyase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation

Proteins

Displaying **all 5** entries
UniProt	Protein Name
G3V9G4	ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme
P16638	ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme
A6HJ38	ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme
A6HJ39	ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme
G3V888	ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
acetyl-CoA metabolic process	IDA
acetyl-CoA biosynthetic process	ISO
acetyl-CoA biosynthetic process	IBA
acetyl-CoA biosynthetic process	IEA
citrate metabolic process	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process

acetyl-CoA metabolic process

acetyl-CoA biosynthetic process

acyl-CoA biosynthetic process

malonyl-CoA metabolic process [inference]

malonyl-CoA biosynthetic process

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

acetyl-CoA metabolic process

acetyl-CoA biosynthetic process

acyl-CoA biosynthetic process

malonyl-CoA metabolic process [inference]

malonyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

acetyl-CoA metabolic process

acetyl-CoA biosynthetic process

acyl-CoA biosynthetic process

malonyl-CoA metabolic process [inference]

malonyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process

fatty acid biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

acetyl-CoA metabolic process

acetyl-CoA biosynthetic process

acyl-CoA biosynthetic process

malonyl-CoA metabolic process [inference]

malonyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

lipid metabolic process

fatty acid metabolic process [inference]

fatty acid biosynthetic process

lipid biosynthetic process

fatty acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

dicarboxylic acid metabolic process [inference]

oxaloacetate metabolic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

tricarboxylic acid metabolic process [inference]

citrate metabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

acetyl-CoA metabolic process

acetyl-CoA biosynthetic process

acyl-CoA biosynthetic process

malonyl-CoA metabolic process [inference]

malonyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process

acetyl-CoA metabolic process

acetyl-CoA biosynthetic process

acyl-CoA biosynthetic process

malonyl-CoA metabolic process [inference]

malonyl-CoA biosynthetic process

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
ciliary basal body

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

microtubule organizing center [inference]

ciliary basal body

cytosol

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
ATP citrate synthase activity	ISO
ATP citrate synthase activity	IDA
ATP citrate synthase activity	IBA
ATP citrate synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, acyl groups converted into alkyl on transfer

ATP citrate synthase activity

lyase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	104112	MGI:103251
Homo sapiens	47	HGNC:115

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026