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Guidelines

MIRAGE

ATPase Na+/K+ transporting subunit alpha 3

Summary

Gene Symbol

Atp1a3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24213

KEGG Gene ID

[""]

PubChem

24213

Alliance of Genome Resources

RGD:2169

Annotation

Keyword

ATP-binding
Cell membrane
Direct protein sequencing
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Sodium/potassium transport
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P06687	Na(+)/K(+) ATPase alpha(III) subunit Sodium pump subunit alpha-3
A0A8L2QEN5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 73 in total

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GO Term	Evidence Code	PMID
potassium ion transport	IDA
potassium ion transport	IEA
sodium ion transport	IDA
sodium ion transport	IEA
intracellular sodium ion homeostasis	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

inhibitory chemical synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

establishment or maintenance of transmembrane electrochemical gradient

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

pore complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection organization [inference]

neuron projection maintenance

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

pore complex assembly

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

circulatory system process [inference]

blood circulation

nervous system process [inference]

transmission of nerve impulse

learning or memory [inference]

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

neuromuscular process

neuromuscular process controlling balance

behavior [inference]

learning or memory [inference]

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

locomotory behavior

visual behavior [inference]

visual learning

adult behavior [inference]

adult locomotory behavior

multicellular organismal response to stress [inference]

fear response

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

growth [inference]

developmental growth [inference]

multicellular organism growth

locomotion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress

multicellular organismal response to stress [inference]

fear response

response to immobilization stress

response to external stimulus [inference]

response to environmental enrichment

response to abiotic stimulus [inference]

response to temperature stimulus

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to electrical stimulus

response to endogenous stimulus [inference]

response to hormone

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to activity

response to chemical [inference]

response to xenobiotic stimulus

response to hormone

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

response to metal ion [inference]

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

response to monoamine

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

establishment or maintenance of transmembrane electrochemical gradient

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

organic anion transport [inference]

carboxylic acid transport

organic acid transport [inference]

carboxylic acid transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

establishment or maintenance of transmembrane electrochemical gradient

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

inhibitory chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
photoreceptor inner segment	ISO
nucleus	ISO
cytoplasm	ISO
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

sodium:potassium-exchanging ATPase complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

cellular anatomical structure [inference]

plasma membrane

sarcolemma

organelle membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

neuron to neuron synapse

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynapse [inference]

axon terminus [inference]

calyx of Held

postsynapse

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
amyloid-beta binding	ISO
amyloid-beta binding	IDA
amyloid-beta binding	IPI
amyloid-beta binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

dopamine receptor binding [inference]

D1 dopamine receptor binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

protein-folding chaperone binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

peptide binding [inference]

amyloid-beta binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
intracellular calcium ion homeostasis
nucleotide binding

Displaying **all 10** entries
InterPro
Cation-transporting P-type ATPase, C-terminal
Cation-transporting P-type ATPase, N-terminal
HAD superfamily
HAD-like superfamily
P-type ATPase, A domain superfamily
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, transmembrane domain superfamily
P-type ATPase

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
sodium	PMID:12093728
dendritic spine neck	PMID:21809413
axon	PMID:12617948
dendritic spine head	PMID:21809413

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Last updated: April 6, 2026