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cytochrome P450, family 1, subfamily a, polypeptide 2

Summary

Gene Symbol

Cyp1a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24297

PubChem

24297

Alliance of Genome Resources

RGD:2459

Annotation

Keyword

Direct protein sequencing
Fatty acid metabolism
Glycoprotein
Heme
Lyase
Membrane
Microsome
Monooxygenase
Reference proteome
Sterol metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
P04799	CYPIA2 Cholesterol 25-hydroxylase Cytochrome P-448 Cytochrome P-450d Cytochrome P450-D Hydroperoxy icosatetraenoate dehydratase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
steroid catabolic process	ISO	http://purl.obolibrary.org/obo/go/references/0000121
steroid catabolic process	IBA	http://purl.obolibrary.org/obo/go/references/0000033
porphyrin-containing compound metabolic process	ISO	http://purl.obolibrary.org/obo/go/references/0000121
xenobiotic metabolic process	ISO	http://purl.obolibrary.org/obo/go/references/0000121
xenobiotic metabolic process	IDA	6772643

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

xenobiotic metabolic process

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

xenobiotic catabolic process

biosynthetic process [inference]

secondary metabolite biosynthetic process [inference]

toxin biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

alkaloid metabolic process

secondary metabolic process [inference]

toxin metabolic process

toxin biosynthetic process

secondary metabolite biosynthetic process [inference]

toxin biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

vitamin E metabolic process

hormone metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

steroid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonate metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process

dibenzo-p-dioxin metabolic process

demethylation [inference]

oxidative demethylation

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

olefinic compound metabolic process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin E

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin E

response to xenobiotic stimulus

response to metal ion [inference]

response to cadmium ion [inference]

cellular response to cadmium ion

response to copper ion [inference]

cellular response to copper ion

cellular response to metal ion [inference]

response to lipid [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

response to nitrogen compound [inference]

response to nitroglycerin

response to oxygen-containing compound [inference]

response to tetrachloromethane

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IBA	http://purl.obolibrary.org/obo/go/references/0000033
endoplasmic reticulum membrane	ISS	http://purl.obolibrary.org/obo/go/references/0000024
endoplasmic reticulum membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	ISO	http://purl.obolibrary.org/obo/go/references/0000121
monooxygenase activity	IDA	12162855
monooxygenase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002
iron ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000002
steroid hydroxylase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [inference]

nitrite reductase (NO-forming) activity

nitrite reductase activity [inference]

nitrite reductase (NO-forming) activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on CH or CH2 groups [inference]

oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [inference]

caffeine oxidase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

hydroperoxy icosatetraenoate dehydratase activity

demethylase activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytochrome P450

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity