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glutamate metabotropic receptor 2

Summary

Gene Symbol

Grm2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24415

PubChem

24415

Alliance of Genome Resources

RGD:2743

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6I2U6
P31421

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IEA
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
glutamate receptor signaling pathway	IMP	28392297
G protein-coupled glutamate receptor signaling pathway	IBA
gene expression	ISO

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular response to stimulus [inference]

cellular response to stress

export from cell [inference]

secretion by cell [inference]

glutamate secretion

multicellular organismal process [inference]

behavior [inference]

adult behavior [inference]

behavioral response to nicotine

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to organic cyclic compound [inference]

response to cocaine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to stress

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

glutamate secretion

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

nitrogen compound transport [inference]

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

amide transport [inference]

glutamate secretion

export from cell [inference]

secretion by cell [inference]

glutamate secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of synaptic plasticity [inference]

long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

regulation of amino acid transport [inference]

regulation of glutamate secretion

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to drug

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of synaptic plasticity [inference]

long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic depression

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS	15993439
plasma membrane	IBA
plasma membrane	IEA
axon	IDA	15993439 28392297
dendrite	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

glial cell projection [inference]

astrocyte projection

presynapse

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	18555800 19590495
scaffold protein binding	IPI	28392297

GO Hierarchy

molecular function

binding [inference]

protein binding

scaffold protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group II metabotropic glutamate receptor activity

glutamate receptor activity [inference]

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group II metabotropic glutamate receptor activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of synaptic transmission, glutamatergic

Displaying **all 6** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9976	heroin dependence	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **120** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2912	Xenbase:XB-GENE-1012087	HUMAN70315
Drosophila melanogaster	2913	FB:FBgn0019985
Caenorhabditis elegans	2914	WB:WBGene00003232
Caenorhabditis elegans	2916	WB:WBGene00003232
Caenorhabditis elegans	2917	WB:WBGene00003232
Caenorhabditis elegans	2918	WB:WBGene00003232
Caenorhabditis elegans	14823	WB:WBGene00003232
Xenopus tropicalis	24415	Xenbase:XB-GENE-1012087
Drosophila melanogaster	24416	FB:FBgn0019985
Caenorhabditis elegans	24417	WB:WBGene00003232

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements