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Fc receptor, IgG, low affinity IV

Summary

Gene Symbol

Fcgr4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

246256

PubChem

246256

Alliance of Genome Resources

MGI:2179523

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
IgE-binding protein
IgG-binding protein
Immunity
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A0B4J1G0	CD16-2 FcgammaRIV

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
antibody-dependent cellular cytotoxicity	IBA
dendritic cell antigen processing and presentation	IMP	28389502
cell surface receptor signaling pathway	IBA
perforin production	ISS
Fc-gamma receptor signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

antibody-dependent cellular cytotoxicity

myeloid leukocyte mediated immunity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

leukocyte degranulation [inference]

natural killer cell degranulation

production of molecular mediator of immune response [inference]

perforin production

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

antigen processing and presentation [inference]

dendritic cell antigen processing and presentation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

perforin production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

perforin production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

perforin production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

perforin production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

perforin production

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

antibody-dependent cellular cytotoxicity

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

perforin production

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

acute inflammatory response [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

localization [inference]

protein-containing complex localization [inference]

Fc receptor-mediated immune complex endocytosis

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

establishment of localization in cell [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

regulation of response to stimulus [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
plasma membrane	ISO
plasma membrane	IDA	28389502
external side of plasma membrane	ISO
external side of plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

Fc receptor complex [inference]

Fc-gamma receptor III complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
IgE receptor activity	IDA	17558411 18949059
IgG receptor activity	IDA	16039578 17558411
IgG receptor activity	IBA
low-affinity IgG receptor activity	ISO
IgE binding	IEA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

GPI anchor binding

glycolipid binding [inference]

GPI anchor binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

carbohydrate derivative binding [inference]

glycolipid binding [inference]

GPI anchor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity

IgG receptor activity

low-affinity IgG receptor activity

immune receptor activity

immunoglobulin receptor activity [inference]

IgE receptor activity

IgG receptor activity

low-affinity IgG receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

low affinity immunoglobulin gamma Fc region receptor III

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
Immunoglobulin-like domain

Ortholog

Displaying entries **31 - 40** of 44 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100387926	CALJA16109
Pongo abelii	100453994	PONAB18212
Ailuropoda melanoleuca	100481923	AILME11914
Otolemur garnettii	100959197	OTOGA15520
Jaculus jaculus	101600950	JACJA14725
Mustela putorius furo	101680253	MUSPF13977
Cavia porcellus	101788791	CAVPO17928
Ictidomys tridecemlineatus	101955076	ICTTR04556
Chinchilla lanigera	102020778	CHILA15435
Capra hircus	102185698	CAPHI22915

GlyTouCan

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OrthoDB (Group)

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Acknowledgements