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phospholipase C, delta 1

Summary

Gene Symbol

Plcd1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24655

KEGG Gene ID

[""]

PubChem

24655

Alliance of Genome Resources

RGD:3346

Annotation

Keyword

3D-structure
Calcium
Direct protein sequencing
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transducer

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A6I3V0
A0A8I5Y0I7
A0A8I6GIK0
P10688	Phosphoinositide phospholipase C-delta-1 Phospholipase C-III Phospholipase C-delta-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
angiogenesis	ISO
lipid metabolic process	IEA
signal transduction	IEA
G protein-coupled receptor signaling pathway	IDA
phospholipase C-activating G protein-coupled receptor signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

intracellular signaling cassette [inference]

phospholipase C/protein kinase C signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphatidylinositol metabolic process

catabolic process [inference]

lipid catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development [inference]

labyrinthine layer blood vessel development

animal organ development [inference]

embryonic organ development [inference]

labyrinthine layer blood vessel development

response to stimulus [inference]

response to stress [inference]

response to hyperoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to increased oxygen levels [inference]

response to hyperoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin F

response to peptide hormone

response to chemical [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin F

response to peptide hormone

response to metal ion [inference]

response to aluminum ion

response to calcium ion

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

response to lipid [inference]

response to prostaglandin [inference]

response to prostaglandin F

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

response to nitrogen compound [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide hormone

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

intracellular signaling cassette [inference]

phospholipase C/protein kinase C signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
cytoplasm	IBA
cytoplasm	IEA
cytosol	ISO
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	ISO
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	EXP
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

C-type glycerophospholipase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

C-type glycerophospholipase activity

phosphatase activity [inference]

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

phosphatidylinositol phosphate binding

phosphatidylinositol-4,5-bisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

alcohol binding [inference]

inositol 1,4,5 trisphosphate binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
lipid metabolic process
metal ion binding
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 8** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain
Phospholipase C, phosphatidylinositol-specific, Y domain